O14133

PR
Gene name
SPAC3C7.07c
Protein name
Arginyl-tRNA--protein transferase 1
Names
Arginyltransferase 1, R-transferase 1, Arginine-tRNA--protein transferase 1
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC3C7.07c
EC number
2.3.2.8: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

272-346 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14133

Entry ID Method Resolution Chain Position Source
AF-O14133-F1 Predicted AlphaFoldDB

7 variants for O14133

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2078553_G_T 42 Q>K No Jeffares_SNPs
I_2078303_T_G 93 K>N No Jeffares_SNPs
I_2078266_C_T 106 E>K No Jeffares_SNPs
I_2078225_T_C 119 I>M No Jeffares_SNPs
I_2077510_G_A 329 L>F No Jeffares_SNPs
I_2077350_C_A 369 W>L No Jeffares_SNPs
I_2077302_T_C 385 Y>C No Jeffares_SNPs

No associated diseases with O14133

2 regional properties for O14133

Type Name Position InterPro Accession
domain N-end aminoacyl transferase, N-terminal 16 - 86 IPR007471
domain N-end rule aminoacyl transferase, C-terminal 139 - 268 IPR007472

Functions

Description
EC Number 2.3.2.8 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
arginyltransferase activity Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.

2 GO annotations of biological process

Name Definition
protein arginylation The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway.
ubiquitin-dependent protein catabolic process via the N-end rule pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVLDKLLYTG YNVSTECGYC KSGRKTEHFG LLAEKLSCED YQRLIDLGWR RSGHYLYKPN
70 80 90 100 110 120
GKTSCCSLYT IRLDSYNFKI AKEQKKAIKK WVKYVNGKPL KPMKSEISTD YLNNAFQTIE
130 140 150 160 170 180
SLGAEKYSVT MEPCTYTDEK FEVFKKYQMQ VHLEKEEEIT KKGFSRFLCN SPLFNEDKGI
190 200 210 220 230 240
KYGSYHQMYR FQGRLVAVGV LDLLPHGVSS VYLFYDPDMS KFSLGRISAC REIWLALECG
250 260 270 280 290 300
YRYYYMGYYI HTCPKMKYKA TYSPSYLLNP GTNKWIPIEN FTSLWNTGAP KYISFGDENN
310 320 330 340 350 360
SDIQTAVDYD SSEDSSQNED DYTLFNRQLP GILSVNVAES LVSENFANIG NSTFPTRHVL
370 380 390
SYFPQVKHWF VEINAAVGEE VAKSYTLVLS S