O14116

PR
Gene name
SPAC328.01c (SPAC3A11.01)
Protein name
Uncharacterized protein C328.01c
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC328.01c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

984-1055 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14116

Entry ID Method Resolution Chain Position Source
AF-O14116-F1 Predicted AlphaFoldDB

17 variants for O14116

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3474559_C_T 56 A>T No Jeffares_SNPs
I_3474556_A_G 57 F>L No Jeffares_SNPs
I_3474406_C_T 107 D>N No Jeffares_SNPs
I_3473983_C_T 248 A>T No Jeffares_SNPs
I_3473919_G_A 269 P>L No Jeffares_SNPs
I_3473877_C_A 283 C>F No Jeffares_SNPs
I_3473392_C_T 445 V>M No Jeffares_SNPs
I_3473227_T_C 500 T>A No Jeffares_SNPs
I_3472974_T_A 584 N>I No Jeffares_SNPs
I_3472509_T_C 739 E>G No Jeffares_SNPs
I_3472070_C_T 885 M>I No Jeffares_SNPs
I_3471925_C_T 934 A>T No Jeffares_SNPs
I_3471908_T_A 939 E>D No Jeffares_SNPs
I_3471736_T_C 997 T>A No Jeffares_SNPs
I_3471644_T_G 1027 K>N No Jeffares_SNPs
I_3471265_C_T 1154 A>T No Jeffares_SNPs
I_3471037_C_A 1230 A>S No Jeffares_SNPs

No associated diseases with O14116

2 regional properties for O14116

Type Name Position InterPro Accession
domain Exportin-1/Importin-beta-like 114 - 280 IPR013598
domain Exportin-5, C-terminal domain 331 - 1187 IPR045478

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RNA nuclear export complex A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore.

4 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein.
nuclear import signal receptor activity Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm.
RNA export from nucleus The directed movement of RNA from the nucleus to the cytoplasm.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDEKGLSNIL QALNVVHSPE SSRETRFSAQ QLLDELKDSY SSPSVAIQLL ELNEQAFSSL
70 80 90 100 110 120
GCKLDIHIVQ HFSLSLFETS VGMNWKSFSN KEKESVTSFL CKISLEDNNL LSVHFVRSKL
130 140 150 160 170 180
ASVFIEIAKR DWYNTWREEF DSFLQSLWSL SLQHRQLSSL ILRGIMEDLY QYDDPVASLR
190 200 210 220 230 240
SHILFNALIS ILSSSSTLHK LYPSGLPYSV TIPSNNEGWL IRWGNALESQ DDALECLKCF
250 260 270 280 290 300
KSCLSWVATD SIREANIVSH ICQILVQGPI FLKTHAIDCI YICVTRTMEI DDPLWEIVEE
310 320 330 340 350 360
MLSPSSLYTL HQVYTATSES INIKTLSSTT PEYILLKKLS ETIVALGQYN YLDSNRRKCI
370 380 390 400 410 420
KLTSLDTYSL LVLEIMKHPS LLISAISQHF WVLALRDPII SKHEKFQIVY PELLSIASER
430 440 450 460 470 480
LLRFEDAVVE LIPESATAKY LQEDVEGVSA VHSFCGNFRR FMFDIVRLTV SITPIESLNW
490 500 510 520 530 540
IQNRFQSTVL GNMEDIQSQT EFFSKTSPLY LTMDVGFSTI EAFLHGVTRW NENTSDDPAT
550 560 570 580 590 600
YEIILQNLFL WCKQLVEINF KDPMLITRLI SVLVLFTSIL ARENTTLLGV VLEKIISAVT
610 620 630 640 650 660
YDNTSASYGF SDVQKINEMR SRCCFELVRL GELMPNPLMN IFDQLQSIID QLDNATTLTG
670 680 690 700 710 720
SEIVMLKTFL FVITQFSDVN IEVKNEYFEK LVGPVVKTWL DVQPPVNSPM EFLNHIGFPQ
730 740 750 760 770 780
MAEYLSAKYP YNADYTQFEL DADAASYQSN LETGRKWLWP IKCLGRFCEA TCSNKHIHPS
790 800 810 820 830 840
EFEGQKNLWQ VILPNVVPNL LKLVEQLHCC YEPSFISGLG MHNSSILQKS IVERFWLHGV
850 860 870 880 890 900
SQISKNQFLE ESYKMDVSAN KLIHSFGHFL RRLREYCYYA IASFMRLGQA FFCVPGLSKQ
910 920 930 940 950 960
FLTAFFSHAA GLSLHQWTSM VNVVIKPYCV NCPAELRDEC LLPLLPALLS ELDHKLVSEW
970 980 990 1000 1010 1020
RRINDRGLLV EEDAEETGED DDLSEEMIEE SLLRHLTYAT AKLITETFLQ ITPTQSRSNV
1030 1040 1050 1060 1070 1080
SSSLIGKETV EGPVKLSEYV LDNAIICEPL LCTLCHLLVI HDSRTVGLVV NAFLAITPLL
1090 1100 1110 1120 1130 1140
VSEQAHSLVR EFICQQVFQS VILAIHDPYF ESMQSDFIRL ACIILSYSQG ITDSAFQLLA
1150 1160 1170 1180 1190 1200
SIPALANQEN LVPAFFNKFR EASTLKIQKA LLTRLLNSGR IVPRTDRRAV NAAILDVSAK
1210 1220 1230
EMLKRFEKSV SLQDEQKNDV LSRDEDTGLA NLFE