O14085

PR
Gene name
sec72 (SPAC2F3.02)
Protein name
Translocation protein sec72
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC2F3.02
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14085

Entry ID Method Resolution Chain Position Source
AF-O14085-F1 Predicted AlphaFoldDB

No variants for O14085

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O14085

No associated diseases with O14085

3 regional properties for O14085

Type Name Position InterPro Accession
repeat Tetratricopeptide repeat 62 - 95 IPR019734-1
repeat Tetratricopeptide repeat 109 - 142 IPR019734-2
repeat Tetratricopeptide repeat 143 - 176 IPR019734-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Sec62/Sec63 complex A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.

2 GO annotations of molecular function

Name Definition
Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.

2 GO annotations of biological process

Name Definition
post-translational protein targeting to endoplasmic reticulum membrane The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVAKQESVVA PQVDVSKWSG KELELGKKVN EYAKSLATFK YPFFIPPPYP PAKPNMALST
70 80 90 100 110 120
QVNKMKQTAN EAFKRKKYEE AKKLYGLALQ LALNRCTWEP SILTREEASV MLCNRAAAEI
130 140 150 160 170 180
ALSQFPEALA DANAALKIRN NYGKCYYRKA KALEAMHRIE EAKQVVRDGL ILAEPVTRNE
190
LVALWASYTE KD