O14077

PR
Gene name
mug138 (SPAC2E11.12c, SPACUNK4.12c)
Protein name
Putative zinc protease mug138
Names
Meiotically up-regulated gene 138 protein
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPACUNK4.12c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

438-507 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O14077

Entry ID Method Resolution Chain Position Source
AF-O14077-F1 Predicted AlphaFoldDB

14 variants for O14077

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2887066_A_G 10 I>V No Jeffares_SNPs
I_2887393_T_C 119 Y>H No Jeffares_SNPs
I_2887783_C_T 249 P>S No Jeffares_SNPs
I_2888267_T_C 410 V>A No Jeffares_SNPs
I_2888384_G_A 449 G>E No Jeffares_SNPs
I_2888390_A_G 451 D>G No Jeffares_SNPs
I_2888690_T_C 551 V>A No Jeffares_SNPs
I_2888852_A_G 605 E>G No Jeffares_SNPs
I_2889229_G_A 731 E>K No Jeffares_SNPs
I_2889344_C_T 769 T>I No Jeffares_SNPs
I_2889394_A_G 786 T>A No Jeffares_SNPs
I_2889631_T_G 865 S>A No Jeffares_SNPs
I_2889643_T_C 869 W>R No Jeffares_SNPs
I_2889781_A_G 915 I>V No Jeffares_SNPs

No associated diseases with O14077

5 regional properties for O14077

Type Name Position InterPro Accession
binding_site Peptidase M16, zinc-binding site 55 - 78 IPR001431
domain Peptidase M16, C-terminal 198 - 366 IPR007863-1
domain Peptidase M16, C-terminal 670 - 849 IPR007863-2
domain Peptidase M16, N-terminal 35 - 171 IPR011765
domain Peptidase M16, middle/third domain 382 - 665 IPR032632

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

3 GO annotations of biological process

Name Definition
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
proteolysis involved in protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDGKPQVEVI VNGQVVPNLD DREYRLIKLE NDLEVLLVRD PETDNASAAI DVHIGSQSNP
70 80 90 100 110 120
RELLGLAHFC EHLLFMGTKK YPDENEYRKY LESHNGISNA YTASNNTNYY FEVSHDALYG
130 140 150 160 170 180
ALDRFAQFFI DPLFLEECKD REIRAVDSEH CKNLQSDSWR FWRLYSVLSN PKSVFSKFNT
190 200 210 220 230 240
GNIETLGDVP KELGLDVRQE LLKFYDKYYS ANIMKLVIIG REPLDVLQDW AAELFSPIKN
250 260 270 280 290 300
KAVPIPKFPD PPYTDNEVRK ICYVKPVKNL RRLDIVFPIP GQYHKYKCRP AEYVCHLLGH
310 320 330 340 350 360
EGEGSYLAYL KSLGLATSLI AFNVSITEDA DIIVVSTFLT EEGLTDYQRV IKILFEYIRL
370 380 390 400 410 420
LDQTNAHKFL FEETRIMSEA QFKTRQKTPA YQYAHVVASK LQREYPRDKV LYYSSVLTEF
430 440 450 460 470 480
DPKGIQEVVE SLRPNNFFAI LAAHSIEKGL DNKEKFYGID YGLEDLDSQF IDSLLHIKTS
490 500 510 520 530 540
SELYLPLANE FIPWSLEVEK QPVTTKLKVP NLVRNDKFVR LWHKKDDTFW VPKANVFINF
550 560 570 580 590 600
ISPIARRSPK VSVSTTLYTR LIEDALGEYS YPASLAGLSF SLSPSTRGII LCISGFTDKL
610 620 630 640 650 660
HVLLEKVVAM MRDLKVHPQR FEILKNRLEQ ELKDYDALEA YHRSNHVLTW LSEPHSWSNA
670 680 690 700 710 720
ELREAIKDVQ VGDMSDFISD LLKQNFLESL VHGNYTEEDA KNLIESAQKL IDPKPVFASQ
730 740 750 760 770 780
LSRKRAIIVP EGGNYIYKTV VPNKEEKNSA IMYNLQISQL DDERSGALTR LARQIMKEPT
790 800 810 820 830 840
FSILRTKEQL GYIVFTLVRQ VTPFINLNIF VQSERSSTYL ESRIRALLDQ FKSEFLEMSD
850 860 870 880 890 900
EDFSKHKSSL INFMLEKHTN LKEESSMYWL RICDGFYDFT RLEKQAEIVS TITKDEFYSF
910 920 930 940 950 960
FINNIHYEGE NTKKISVHVV SQRCEDEVYE IPNVTIIENG NMFKESMTLS KAAFPLKPFD
EIDRSLLFN