O14047

PR
Gene name
ppk11 (SPAC2C4.14c)
Protein name
Serine/threonine-protein kinase ppk11
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC2C4.14c
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

246-312 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

144-167 (Activation loop from InterPro)

Target domain

6-258 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O14047

Entry ID Method Resolution Chain Position Source
AF-O14047-F1 Predicted AlphaFoldDB

1 variants for O14047

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4284276_T_G 60 N>H No Jeffares_SNPs

No associated diseases with O14047

2 regional properties for O14047

Type Name Position InterPro Accession
domain Protein kinase domain 6 - 258 IPR000719
binding_site Protein kinase, ATP binding site 12 - 35 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Located at the septum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
division septum A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
protein localization to cell division site A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of establishment or maintenance of bipolar cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKHQYRDLQ LIGQGSFGSV FRAQDVESSK IVALKVVDLD ATKDQIETLT QEINFLIDLN
70 80 90 100 110 120
SVHITKYYAS FVDGFRLWIT MEYCDGGSCL DLLKLSGTFS ERVIAEVMRQ VLEALVYLHG
130 140 150 160 170 180
QGKMHRDIKA ANILTMKDGL VKLADFGVSG QLESLRDKND DFVGTPFWMA PEVVKQTGYN
190 200 210 220 230 240
YKADIWSLGI TAYELATGEP PYSGIHPMKV LLLIPKHSPP SLERSKFSRA FCDFVSNCLK
250 260 270 280 290 300
KNPKDRATAE YLSKHKFIKK YCPNTSVKEV VASYAKWKES ELLPEATPYN STMGNSANTI
310
DEVVWDFGTV RR