O13988

PR
Gene name
pot1 (SPAC26H5.06)
Protein name
Protection of telomeres protein 1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC26H5.06
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

113-225 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

18 structures for O13988

Entry ID Method Resolution Chain Position Source
1QZG X-ray 190 A A/B 2-185 PDB
1QZH X-ray 240 A A/B/C/D/E/F 2-185 PDB
4HID X-ray 182 A A 198-339 PDB
4HIK X-ray 164 A A 198-339 PDB
4HIM X-ray 175 A A 198-339 PDB
4HIO X-ray 175 A A 198-339 PDB
4HJ5 X-ray 204 A A 198-339 PDB
4HJ7 X-ray 178 A A 198-339 PDB
4HJ8 X-ray 204 A A 198-339 PDB
4HJ9 X-ray 185 A A 198-339 PDB
4HJA X-ray 210 A A 198-339 PDB
5USB X-ray 161 A A 200-337 PDB
5USN X-ray 190 A A 200-339 PDB
5USO X-ray 200 A A 200-337 PDB
6BWY X-ray 290 A A/B/E/G 5-174 PDB
7CUH X-ray 300 A A 1-339 PDB
7CUI X-ray 260 A A/C 357-555 PDB
AF-O13988-F1 Predicted AlphaFoldDB

9 variants for O13988

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4129560_T_C 11 L>S No Jeffares_SNPs
I_4130181_G_A 179 G>S No Jeffares_SNPs
I_4130221_C_A 192 T>N No Jeffares_SNPs
I_4130324_T_A 226 D>E No Jeffares_SNPs
I_4130758_T_A 371 V>D No Jeffares_SNPs
I_4130949_G_A 435 V>I No Jeffares_SNPs
I_4131000_G_A 452 V>I No Jeffares_SNPs
I_4131066_G_A 474 A>T No Jeffares_SNPs
I_4131235_T_C 530 V>A No Jeffares_SNPs

No associated diseases with O13988

2 regional properties for O13988

Type Name Position InterPro Accession
domain Telomeric single stranded DNA binding POT1/Cdc13 27 - 171 IPR011564
domain Protection of telomeres protein 1, ssDNA-binding domain 203 - 338 IPR032042

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, telomere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
chromosome, telomeric repeat region A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear telomere cap complex A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
shelterin complex A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1.
telomere cap complex A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.

3 GO annotations of molecular function

Name Definition
G-rich strand telomeric DNA binding Binding to G-rich, single-stranded, telomere-associated DNA.
single-stranded telomeric DNA binding Binding to single-stranded telomere-associated DNA.
telomerase inhibitor activity Binds to and stops, prevents or reduces the activity of telomerase.

5 GO annotations of biological process

Name Definition
negative regulation of telomerase activity Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
negative regulation of telomere maintenance via telomerase Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
regulation of telomere maintenance via telomerase Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase.
telomere capping A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGEDVIDSLQ LNELLNAGEY KIGELTFQSI RSSQELQKKN TIVNLFGIVK DFTPSRQSLH
70 80 90 100 110 120
GTKDWVTTVY LWDPTCDTSS IGLQIHLFSK QGNDLPVIKQ VGQPLLLHQI TLRSYRDRTQ
130 140 150 160 170 180
GLSKDQFRYA LWPDFSSNSK DTLCPQPMPR LMKTGDKEEQ FALLLNKIWD EQTNKHKNGE
190 200 210 220 230 240
LLSTSSARQN QTGLSYPSVS FSLLSQITPH QRCSFYAQVI KTWYSDKNFT LYVTDYTENE
250 260 270 280 290 300
LFFPMSPYTS SSRWRGPFGR FSIRCILWDE HDFYCRNYIK EGDYVVMKNV RTKIDHLGYL
310 320 330 340 350 360
ECILHGDSAK RYNMSIEKVD SEEPELNEIK SRKRLYVQNC QNGIEAVIEK LSQSQQSENP
370 380 390 400 410 420
FIAHELKQTS VNEITAHVIN EPASLKLTTI STILHAPLQN LLKPRKHRLR VQVVDFWPKS
430 440 450 460 470 480
LTQFAVLSQP PSSYVWMFAL LVRDVSNVTL PVIFFDSDAA ELINSSKIQP CNLADHPQMT
490 500 510 520 530 540
LQLKERLFLI WGNLEERIQH HISKGESPTL AAEDVETPWF DIYVKEYIPV IGNTKDHQSL
550
TFLQKRWRGF GTKIV