O13923
Gene name |
crn1 (SPAC23C4.02) |
Protein name |
Coronin-like protein crn1 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC23C4.02 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O13923
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O13923-F1 | Predicted | AlphaFoldDB |
7 variants for O13923
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1033727_A_G | 456 | T>A | No | Jeffares_SNPs | |
| I_1033739_G_A | 460 | A>T | No | Jeffares_SNPs | |
| I_1033770_G_T | 470 | R>L | No | Jeffares_SNPs | |
| I_1033800_C_T | 480 | T>I | No | Jeffares_SNPs | |
| I_1033883_G_A | 508 | D>N | No | Jeffares_SNPs | |
| I_1033989_T_C | 543 | F>S | No | Jeffares_SNPs | |
| I_1034130_C_A | 590 | A>D | No | Jeffares_SNPs |
No associated diseases with O13923
7 regional properties for O13923
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 70 - 119 | IPR001680-1 |
| repeat | WD40 repeat | 123 - 163 | IPR001680-2 |
| repeat | WD40 repeat | 166 - 251 | IPR001680-3 |
| domain | Domain of unknown function DUF1899 | 4 - 69 | IPR015048 |
| repeat | G-protein beta WD-40 repeat | 97 - 111 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 150 - 164 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 191 - 205 | IPR020472-3 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cortical patch | An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. |
| actin fusion focus | A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location. |
| cell tip | The region at the end of the longest axis of a cylindrical or elongated cell. |
| endocytic vesicle | A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. |
| mitotic actomyosin contractile ring | A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament bundle assembly | The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. |
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| actin filament polymerization | Assembly of actin filaments by the addition of actin monomers to a filament. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGRFVRASK | YRHIFGQTCK | KELCYDNIKL | SNNAWDSNLL | SVNPFYLSVN | WNAGAGGALA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VIPLNERGKL | PDQVNLFRGH | TAAVLDTDWN | PFHDQVLASG | GDDSKIMIWK | VPEDYTVMEP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YEDVHPIAEL | KGHSRKVGLV | QYHPTAANVL | ASSSADNTIK | LWDCEKGVAH | VSLKMDVMCQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SMSFNADGTR | LVTTSRDKKV | RVWDPRTDKP | VSVGNGHAGA | KNPRVVWLGS | LDRFATTGFS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KMSDRQIALW | DPTNLSEPIG | GFTTLDTGSG | ILMPFWDDGT | KVIYLAGKGD | GNIRYYEYEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DVFHYLSEFK | SVDPQRGIAF | LPKRGVNVSE | NEVMRAYKSV | NDSIIEPISF | IVPRRSESFQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SDIYPPAPSG | KPSLTAEEWA | SGKDAQPDLL | DMSTLYESKG | TVEKAVSATV | PSAGAQVQKH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NEEKVETPKP | EAQPVSKPKE | SAEEQKPSKE | PEVKPTTPSA | SKVEEPSKKR | DEDNHQKEET |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VTQPKREKTP | VEKSFPKPAS | SPVTFSEDVK | KEPSEEKKLE | VSDEAPKAAP | LAESKKVEEK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EPFYVSKDKK | DISAVNLADL | NKRFEGFEKR | YEEELAIRDW | KIAQLEDKLA | KLTEAIKEKC |
| N |