O13898

PR
Gene name
ogm1 (oma1, SPAC22A12.07c)
Protein name
Dolichyl-phosphate-mannose--protein mannosyltransferase 1
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC22A12.07c
EC number
2.4.1.109: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

806-893 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13898

Entry ID Method Resolution Chain Position Source
AF-O13898-F1 Predicted AlphaFoldDB

9 variants for O13898

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1169377_C_T 43 V>M No Jeffares_SNPs
I_1168878_G_A 209 S>F No Jeffares_SNPs
I_1168663_G_T 281 H>N No Jeffares_SNPs
I_1167895_C_A 537 G>C No Jeffares_SNPs
I_1167693_C_G 604 G>A No Jeffares_SNPs
I_1167471_G_A 678 A>V No Jeffares_SNPs
I_1167225_T_C 760 N>S No Jeffares_SNPs
I_1167022_A_T 828 L>M No Jeffares_SNPs
I_1167002_T_A 834 E>D No Jeffares_SNPs

No associated diseases with O13898

3 regional properties for O13898

Type Name Position InterPro Accession
domain Glycosyl transferase family 39/83 39 - 283 IPR003342
domain MIR motif 310 - 499 IPR016093
domain Protein O-mannosyl-transferase, C-terminal four TM domain 518 - 710 IPR032421

Functions

Description
EC Number 2.4.1.109 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Nucleus membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

1 GO annotations of molecular function

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

3 GO annotations of biological process

Name Definition
cell wall mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.
chain elongation of O-linked mannose residue Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules.
protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKQSTFQDP KEKHRIQRDV KLSRPRKRFS FLDYVVVIFL TVVAFCVRAQ RLMNPAKVVF
70 80 90 100 110 120
EELRYYNYAV DYVNNKLLMD VYPPLGKLLF SLVAALTGNK YELNTLDEPG QQYPFTDVAY
130 140 150 160 170 180
SMRLFTCLLG SLLVPLMYGT VYFPTKSKTA ASLAALFVIF DNGLITMSRY IMIEIPALYF
190 200 210 220 230 240
MSLTAFYWSV YEAQQKRPFS LRWHTSLLST GVALGLALST KLSAMFTFGW LLILAAFHLW
250 260 270 280 290 300
NLLGDLSVPM YRIVKHLFSY IFYLIGVPIT VYLAVFAVHS HIAYKASVAD AFLPPEHRHA
310 320 330 340 350 360
LAGNRFDDQF ADVAYGSLVT IRNAIPEHGY LHSSELLYPE GTEQQIISLV DEPNQNALWI
370 380 390 400 410 420
IEHEHSQDNN RSNIELLKDG SVVRLRHVMT GRALHSHEHK PIVSNNDWQL EASAYGGFGF
430 440 450 460 470 480
EGDANDLFRI QILEKKSKHA TSNGTVETLN TKFRLIHVFA NCELMSSHRR FPDWGDYQRE
490 500 510 520 530 540
VTCCRNCVER STTWFIESNY HDGLPSDSRK ITYRKPGFLE SFVEHNKLMW LKDRKMGDGH
550 560 570 580 590 600
VYESSALTWP LLLGPLRFFY EQHLQVFFMG NPFVWYSVIS LVAFFVIVQI FCLARWNLGY
610 620 630 640 650 660
NDFGPSAFHY NYNIGKFVVA WLLHWAPYIL ETDRVFLYHY LPALYFGIAA LGVSWSFLGN
670 680 690 700 710 720
AVFGNRTAYK ALSVIIMALM FLVYRLYSPF TYMTTLTKSS CRALELKGSW NFHCNTYLDN
730 740 750 760 770 780
LSDYKFSSDA GETYFEKAAP HPFVYSEDTA KKSEGDTPLN KNLNDYYPSW DQRVEAGYKL
790 800 810 820 830 840
AAQQKAEQEA REAAEKAASE AAERSSSEAA ASSSSESVAA ASVEAERLAM EADEFNGASE
850 860 870 880 890
TVDGASVEAE RSAMEAAALN NAAESTEVVG SSPESVASEQ EENVAESAQA RVE