O13861
Gene name |
SPAC1A6.10 (SPAC30D11.05c) |
Protein name |
tRNA threonylcarbamoyladenosine dehydratase |
Names |
t(6)A37 dehydratase |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC1A6.10 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O13861
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O13861-F1 | Predicted | AlphaFoldDB |
6 variants for O13861
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1090889_A_G | 71 | K>R | No | Jeffares_SNPs | |
| I_1091575_G_A | 300 | D>N | No | Jeffares_SNPs | |
| I_1091771_C_G | 365 | T>S | No | Jeffares_SNPs | |
| I_1091818_G_A | 381 | A>T | No | Jeffares_SNPs | |
| I_1091999_C_A | 441 | T>K | No | Jeffares_SNPs | |
| I_1092049_G_A | 458 | D>N | No | Jeffares_SNPs |
No associated diseases with O13861
5 regional properties for O13861
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 357 - 561 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 128 - 275 | IPR011545 |
| domain | ATP-dependent RNA helicase Ski2/MTR4, C-terminal | 852 - 1030 | IPR012961 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 122 - 305 | IPR014001 |
| domain | rRNA-processing arch domain | 566 - 826 | IPR025696 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| tRNA threonylcarbamoyladenosine dehydratase | Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A. |
| ubiquitin-like modifier activating enzyme activity | Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cyclic threonylcarbamoyladenosine biosynthetic process | The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| METLQVEVFF | LFDFTSIMAG | FKVPSWITYK | SFWIAVSSSV | TTACVILGTL | EFRKHRSIRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQSMIVPEAG | KSIQLSSSGV | PIEIYDAGEE | DEGISKGVPY | DENLIREQLA | RNYAFFGEDG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MERLRNSFVI | VVGCGGVGSW | VINMLARSGV | QKIRIVDFDQ | VSLSSLNRHS | IATLQDVGTP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KTLAIKKAIK | KFAPWIEVDA | RNALFNPDSA | DDLLSGNPDF | VIDAIDNIQT | KVDLLSYCYN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HKLPVIASTG | SACKSDPTRV | NIADISATSE | DPLSRATRRR | LRLLGIMEGI | PVVFSTEKPD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRKASLLPLS | EEEFEKGDVD | ELSALPEFRA | RILPVIGPMP | GIFGLTIATY | VLTSIAKYPM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DPISTMTRPR | LYEEAVKRLH | AEARKAGVNL | DKTFNASEMS | YIIEEVYVGR | SALPPHESQK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VTVVRWNPQL | PFDHTNLVAM | TRNEARYHED | NVLAKNVDPS | TVYGKDVIEV | VHSFLRRLRM |
| WEMLY |