O13853

PR
Gene name
its3 (SPAC19G12.14)
Protein name
Phosphatidylinositol 4-phosphate 5-kinase its3
Names
1-phosphatidylinositol 4-phosphate kinase, Diphosphoinositide kinase, PIP5K, PtdIns(4)P-5-kinase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC19G12.14
EC number
2.7.1.68: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

41-271 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13853

Entry ID Method Resolution Chain Position Source
AF-O13853-F1 Predicted AlphaFoldDB

3 variants for O13853

Variant ID(s) Position Change Description Diseaes Association Provenance
I_4072417_A_G 14 I>M No Jeffares_SNPs
I_4072536_G_A 54 R>H No Jeffares_SNPs
I_4072928_C_T 185 R>W No Jeffares_SNPs

No associated diseases with O13853

1 regional properties for O13853

Type Name Position InterPro Accession
domain Phosphatidylinositol-4-phosphate 5-kinase, core 264 - 663 IPR002498

Functions

Description
EC Number 2.7.1.68 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Nucleus
  • Membrane; Peripheral membrane protein
  • The active form of the enzyme is membrane-associated and concentrates at the septum in dividing cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
division septum A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
1-phosphatidylinositol-3-phosphate 4-kinase activity Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).
1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
phosphatidylinositol-3,4-bisphosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

4 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
dynein-driven meiotic oscillatory nuclear movement Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein.
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKIDSNGIVN PHSITNEIPS YDEKQAVDLN GNAFAPNGTF QKKDLISHKN DFERTMRHDV
70 80 90 100 110 120
LHTNPKIEVR SETHIYEPND SLFKENQDFP SNPTAHSPSS SSNDSVITAT GVPDGILRDS
130 140 150 160 170 180
PIVSALEPPS SNSSSSPQLQ NLKHQLSSPQ PSRAPIDRSS SNPVTSSQQP PNDRSTLSSS
190 200 210 220 230 240
QKAKRPLKRS YSEKNSSNAE PSGSRSGDRG TNVSTSGSLL DGIPPDIGSA SWAEAVKQKR
250 260 270 280 290 300
VNMRRRREEL DDECVLVGTR VSEGHENYVT AYNMLTGIRV GVSRCQAKMD RELTPADFTA
310 320 330 340 350 360
RHKFTFDITG NELTPSAKYD FKFKDYAPWV FRHLRQLFHL DAADYLVSLT SKYILSELDS
370 380 390 400 410 420
PGKSGSFFYF SRDYRFIIKT IHHSEHKFLR EILYDYYEHV KNNPNTLISQ FYGLHRVKLP
430 440 450 460 470 480
FGRKIHFVVM NNLFPPHRDI HQTFDLKGST LGRELDENQP CQSPMCTMKD TNWIRRNMHL
490 500 510 520 530 540
QFGPLKRQIF LTQVKADIDM LSSLGIMDYS LLVGIHDLSR GNRDKIRNSI LSVYDPNVSQ
550 560 570 580 590 600
HRVPSINGNE SHSNVHVIRQ VVNSTGPVSL DQSCNLLPTD QFVERRNFMF YSDDGGFQAT
610 620 630 640 650 660
DENNEPGNFI FYIGIIDLLT KYSYVKRVEH LWKGINHSDS VISAVPPAEY ASRFYKFVES
670 680 690 700 710 720
SIKPTLLVLK PFPLKPQDGQ RVNKQQSVNA GNVRTNNKHG SLNNNTAPSS RNAKSTSAHK
730 740
SPKTEHRFPF PCRNVTTNTS SS