Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O13816
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O13816-F1 | Predicted | AlphaFoldDB |
15 variants for O13816
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_2036490_A_T | 30 | M>L | No | Jeffares_SNPs | |
| I_2037080_C_T | 183 | L>F | No | Jeffares_SNPs | |
| I_2037320_G_A | 263 | V>I | No | Jeffares_SNPs | |
| I_2037330_A_G | 266 | N>S | No | Jeffares_SNPs | |
| I_2037968_A_G | 462 | Q>R | No | Jeffares_SNPs | |
| I_2038019_G_C | 479 | C>S | No | Jeffares_SNPs | |
| I_2038157_T_C | 525 | I>T | No | Jeffares_SNPs | |
| I_2038223_A_T | 547 | D>V | No | Jeffares_SNPs | |
| I_2038370_C_T | 596 | T>M | No | Jeffares_SNPs | |
| I_2038396_G_T | 605 | D>Y | No | Jeffares_SNPs | |
| I_2038570_T_A | 663 | F>I | No | Jeffares_SNPs | |
| I_2038909_T_C | 776 | F>L | No | Jeffares_SNPs | |
| I_2039184_C_A | 851 | D>E | No | Jeffares_SNPs | |
| I_2039458_T_G | 943 | C>G | No | Jeffares_SNPs | |
| I_2039482_C_T | 951 | P>S | No | Jeffares_SNPs |
No associated diseases with O13816
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromosome, subtelomeric region | A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin. |
| cohesin complex | A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). |
| mating-type region heterochromatin | Heterochromatic regions of the chromosome found at silenced mating-type loci. |
| mitotic cohesin complex | A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| pericentric heterochromatin | Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3). |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| chromatin looping | A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome. |
| mitotic cohesin loading | The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle. |
| mitotic sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. |
| sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSESVTTGSD | DDGGDRESSP | VMLSQSFDPM | SSSSNSSSEE | NSDDDYEKTI | SSKKRHPRPN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SKGVNVKRSR | RNAIVEEDPQ | EEIFNNLFAF | LLDQKVDTMD | IAVSWFADYA | KDNQSALANL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INFILKCCGC | NRAINVFDVQ | DQDSASATLS | QIQLSVERTS | TRDYPLNSKN | LKFRNFRKRL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TGLLSNFVSQ | LSIRNYLYNS | TVFEDIMSWV | VAMSSSTMRP | IRHTATVFCL | NIMTFLCEKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KELLNEHAIA | TKQLEKEEKR | SRVNRNRINE | LNNSLGEIVK | QQDTLTTYLN | DYFDSVFVHR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YRDVEPKIRV | DCLQELGVWI | NTVPSIFFSG | SYLRYLGWML | SDINTTVRLT | VVKVLRKFFE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TDSFIGGLRH | FSSRFKERIL | EMSCVDADIG | VRVASIRLCN | AMRTCGFLEN | SEILKVLKLI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LDINPRVQRE | AVLFLCKVVD | ESVNEKIDLW | GEEDYILKAF | SQTSLTTFSV | HWIKFSQMCK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLEEVRLSYQ | SSFDYDTLLR | IFQKNGNFIT | PITQALLNAC | EIDSIYQSWE | DISNFVLFDN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YTSTLKDPID | SILSFCKLND | FQESILLQLL | SASIQTVCNN | NFITPKTVHN | KQAAETTNDQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NKDKDLLYLN | LLPYINSITE | RNSASPTLLH | DSLRLLFSMD | LTEMTDPQLS | RHFELLINNL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KKFFLTNNDL | QIIQGCTILF | LRLDSIPALK | EDLKLLVTDI | CDQTVTEFLK | NFGSFNIQDA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VITKDEFVIF | EACLTRIEGC | TSLKDFSDYP | EFDIIYERLV | SLLSRVPNSY | EDTLKFSAIN |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TLQSLLFWFF | LRKDNPADEE | KKKDDETKVF | NCLINIMNND | SSKILQLQAA | RTFLETVIMK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| EGVKASHYND | DNRVSEEHNF | LKPQFLDALL | KILEGWLYTY | AKVGQFPFKR | LTQASSPHTQ |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ISLDKNPLNR | RLLEHVCCDL | TSKLLIVVSL | SNTITPEFSQ | QFCELRGHYG | PKLSAIVDEF |
| LN |