O13792

PR
Gene name
uap56 (sub2, SPAC17G6.14c)
Protein name
ATP-dependent RNA helicase uap56
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC17G6.14c
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13792

Entry ID Method Resolution Chain Position Source
AF-O13792-F1 Predicted AlphaFoldDB

2 variants for O13792

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3618757_G_A 30 A>V No Jeffares_SNPs
I_3618256_C_T 197 S>N No Jeffares_SNPs

No associated diseases with O13792

No regional properties for O13792

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O13792

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription export complex The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

3 GO annotations of biological process

Name Definition
mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule.
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASAQEDLID YEEEEELVQD QPAQEITPAA DTAENGEKSD KKGSYVGIHS TGFRDFLLKP
70 80 90 100 110 120
ELLRAITDSG FEHPSEVQQV CIPQSILGTD VLCQAKSGMG KTAVFVLSTL QQIEPVDGEV
130 140 150 160 170 180
SVLVLCHTRE LAFQIKNEYA RFSKYLPDVR TAVFYGGINI KQDMEAFKDK SKSPHIVVAT
190 200 210 220 230 240
PGRLNALVRE KILKVNSVKH FVLDECDKLL ESVDMRRDIQ EVFRATPPQK QVMMFSATLS
250 260 270 280 290 300
NEIRPICKKF MQNPLEIYVD DETKLTLHGL QQHYVKLEEK AKNRKINDLL DSLEFNQVVI
310 320 330 340 350 360
FVKSVSRANE LDRLLRECNF PSICIHGGLP QEERIKRYKA FKDFDKRICV ATDVFGRGID
370 380 390 400 410 420
IERVNIVINY DMPDSPDSYL HRVGRAGRFG TKGLAITFSS SEEDSQILDK IQERFEVNIT
430
ELPDEIDVGS YMNA