O13786

PR
Gene name
pep7 (vac1, SPAC17G6.08)
Protein name
Vacuolar segregation protein pep7
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC17G6.08
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13786

Entry ID Method Resolution Chain Position Source
AF-O13786-F1 Predicted AlphaFoldDB

2 variants for O13786

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3603195_A_G 439 I>M No Jeffares_SNPs
I_3603289_G_C 471 E>Q No Jeffares_SNPs

No associated diseases with O13786

6 regional properties for O13786

Type Name Position InterPro Accession
domain FYVE zinc finger 126 - 202 IPR000306-1
domain FYVE zinc finger 267 - 333 IPR000306-2
domain Zinc finger C2H2-type 41 - 62 IPR013087
domain Zinc finger, FYVE-related 145 - 201 IPR017455-1
domain Zinc finger, FYVE-related 275 - 332 IPR017455-2
domain Rabenosyn, Rab binding domain 483 - 523 IPR021565

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic side of endosome membrane The side (leaflet) of the endosome membrane that faces the cytoplasm.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.

3 GO annotations of biological process

Name Definition
Golgi to vacuole transport The directed movement of substances from the Golgi to the vacuole.
vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.
vesicle fusion Fusion of the membrane of a transport vesicle with its target membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQNGKRRIGV RISSNLSNHS GTNLSTSAQS DSSNIVKATE CPICGLELPN LSALNDHLDV
70 80 90 100 110 120
THFNDNEKIH KRQDSINSWL TRTLNGASAL QMKAAQRLWR MEPYEQNGDS SGAVGLEATK
130 140 150 160 170 180
LTDSLVVKNH WQPEVPDMVC HDPMCDKLLN FINGHIHCRK CGYIFCNFHS MYQIKLSIHA
190 200 210 220 230 240
TYDSENGFWC RVCRECYEGR PGYNDSNGLI RSRFQTFETF RKPLADKRRI EFLRLSKRMK
250 260 270 280 290 300
KLEELWTSEN VSMLDALLLN KAKRLEQSIV HWQDDSVVQI CPECNNSFTL TRRRRHCRLC
310 320 330 340 350 360
GRVICRFCVL EISLPQHPQP LLICMSCNQN YFRNVLYQTE RSKSLGYIRH IEHLQVFRQA
370 380 390 400 410 420
MVNYYRLYED SLSELLSGEI ITEATLKIVK DRRKKFLELC VKYDGTMKKI ANHPSSNDAE
430 440 450 460 470 480
EQFKQNVVNE AKRYLQETIL RLQAIPYHLQ VGQAWTSESE RELEKKKEQV EKKQEELMQT
490 500 510 520 530
RIVLEEQVFL VENMIEDAKA KRKFSEVETL LSSLAPLHEE IHSITEKIHD LDLFDI