O13742

PR
Gene name
vph1 (SPAC16E8.07c)
Protein name
V-type proton ATPase subunit a
Names
V-ATPase a subunit, Vacuolar ATPase 91 kDa subunit, Vacuolar proton pump a subunit, Vacuolar proton translocating ATPase subunit a
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC16E8.07c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-226 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13742

Entry ID Method Resolution Chain Position Source
AF-O13742-F1 Predicted AlphaFoldDB

5 variants for O13742

Variant ID(s) Position Change Description Diseaes Association Provenance
I_3512340_C_T 192 S>N No Jeffares_SNPs
I_3511726_C_T 397 V>I No Jeffares_SNPs
I_3511078_T_C 613 K>E No Jeffares_SNPs
I_3510925_T_C 664 I>V No Jeffares_SNPs
I_3510797_T_A 706 Q>H No Jeffares_SNPs

No associated diseases with O13742

No regional properties for O13742

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O13742

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.
vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism.

2 GO annotations of biological process

Name Definition
proton transmembrane transport The directed movement of a proton across a membrane.
vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSPSLFRSEE VSLVQLYLPT ESARPIMSAL GELSTIHFKD LNPDVVAFQR SFVREIRRLT
70 80 90 100 110 120
DTERLLRYLH SEIDLNGIHV PDHNLPPSYE SVLESSTIED IIERITRLEA RVRQLVESSQ
130 140 150 160 170 180
LLEARYLQQL EFANVLTKAD AFFSKSGNTV DPLRNNYETS SIFSGEDDTT APLIENALEL
190 200 210 220 230 240
GTTGTFDSEE TSPQMNTTLD FVSGIIPTVK FQFLERILWR TLRGNLFIHQ VRADDSLIHG
250 260 270 280 290 300
AEKNEEKTIF LVIAHGTQIL LRIRKISESL GATLFPVEED APGRTSQIQQ ANVSISDLNA
310 320 330 340 350 360
VLENTRSALY TELTFIAEHI SAWEAVLHKD KTVFQVMNLF NYDQNHKCLI AEGWCPTANL
370 380 390 400 410 420
PMVQKTLRNI SDLTDSQAPT ILNVVHTSEQ PPTYFRVNKF TEGFQSIIDS YGIATYREVN
430 440 450 460 470 480
HGIVAIVTFP FLFAIMFGDL GHGAIMASVA LMFVLYEKTL GAKKDLDEIV GMVFYGRYIV
490 500 510 520 530 540
LLMGLFSMYV GFVYNDLFSK PMSIFSSRWV WPVKSEEAIA RAVQVGTYPI GIDPTWHSAD
550 560 570 580 590 600
NNLLFMNSYK MKLSIILGVI HMTFCLFLSL SNYRFFKRKL DIYAVFVPSL IFLEAIFGYL
610 620 630 640 650 660
VITIVYKWCI DWKAKDLQPP SLLNMLILMF LSPGTLEDQL YPGQKYLQVG LVIAALICVP
670 680 690 700 710 720
WLLIVKPFVL WRRHSNEENK YQSLNSDLPN VDEADALMAV DSQEKQAEPF ELGEVVIHQV
730 740 750 760 770 780
IHTIEFCLGC VSHTASYLRL WALSLAHNQL SSVLWNMTLA NGFRMTGIVG SIFVVILFGF
790 800 810 820 830
WFIATCVVLV AMEGTSAMLH SLRLHWVEGM SKHFEGEGYA FTPFTFKVTA E