O13705

PR
Gene name
sec10 (SPAC13F5.06c)
Protein name
Exocyst complex component sec10
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC13F5.06c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

51-160 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13705

Entry ID Method Resolution Chain Position Source
AF-O13705-F1 Predicted AlphaFoldDB

17 variants for O13705

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2183937_G_C 55 I>M No Jeffares_SNPs
I_2183507_C_A 199 A>S No Jeffares_SNPs
I_2183377_G_A 242 A>V No Jeffares_SNPs
I_2183067_C_G 345 K>N No Jeffares_SNPs
I_2182631_T_A 491 I>F No Jeffares_SNPs
I_2182614_G_T 496 N>K No Jeffares_SNPs
I_2182613_G_A 497 H>Y No Jeffares_SNPs
I_2182607_G_A 499 H>Y No Jeffares_SNPs
I_2182599_A_C 501 N>K No Jeffares_SNPs
I_2182456_A_C 549 F>C No Jeffares_SNPs
I_2182412_T_C 564 K>E No Jeffares_SNPs
I_2182379_C_T 575 D>N No Jeffares_SNPs
I_2182223_A_G 627 F>L No Jeffares_SNPs
I_2182213_G_A 630 T>I No Jeffares_SNPs
I_2182066_T_C 679 K>R No Jeffares_SNPs
I_2181985_A_C 706 M>R No Jeffares_SNPs
I_2181611_G_A 798 Q>* No Jeffares_SNPs

No associated diseases with O13705

No regional properties for O13705

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O13705

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name Definition
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
vesicle tethering involved in exocytosis The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTKNALNDS QIKLLNSLND NKGIPSTEFV EKFAESLYET QNDGSKKLSS IDGSIKSFAA
70 80 90 100 110 120
CLHELNRLKS RVGDRIRDYA SASKQVQNEY HQKSNHLREK FAQVLELSRH LEDNVNDMRS
130 140 150 160 170 180
GLVDAGQELE RAENNRKRIL SSAELLRYYL EFRSGKPQTL MDFFRTNNHD KMLLCAQRTR
190 200 210 220 230 240
QLLALANEVD LPDSSETLAR IEKFSEFLET NFLKFFNNEY RKPNWKGMAS FGTILQEFNG
250 260 270 280 290 300
GASVVREFVN QHEFFIAADK VQSRQGLEQD PIWLILPDPT QKIPPLIQTL SSLFSELCSV
310 320 330 340 350 360
IEGDCAVIKR VFPNPELVLQ TFFQRIFGQS IQNRLEEVME IAKGKSNLAY LRTLQTVVSS
370 380 390 400 410 420
LRKLVADLKT ILENRGFSVS DNSPLSLALN QYMEDLLVPF IEVDDYLKRE EHSLRSLFRL
430 440 450 460 470 480
SLYKYTSYKI RLETPEPGLL RSLMTPLQGN MVAPTGVHSQ FNTKTEGFLL RIADIQENLI
490 500 510 520 530 540
QSGSFITEDY ITIEKNHSHL NSEKVYSFIG WHAEALNRAS ILISSQDLSV VISSLVNLLD
550 560 570 580 590 600
KLIREDYVFK ELSSIQSYIS SHDKSKNLDL HYLVDIRECK KIMGYFSAYL MSIVIPFTGV
610 620 630 640 650 660
TASSRRETVN ILSSSISVIE CAVNDVFYAT VHALGDHLEI ILSPYRQISY AMTEEQIDSS
670 680 690 700 710 720
TELRQSMTRN VQNYLDYIKN LYHRLGPYDP SLLALKQKTA TMLAAMLISF AFRSKVTAAG
730 740 750 760 770 780
ALLLQNDINF FHSTLTSWGI DTVDAKFKLI LQLLSLLMVK IDVLPAVMQD KRKAGFSEMN
790 800 810
IHEVLRLRFD LPENLKLQLN KEEALLPPKS S