O13636

PR
Gene name
tim50 (pi044, SPBC17A3.01c, SPBC8D2.21c)
Protein name
Mitochondrial import inner membrane translocase subunit tim50
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC17A3.01c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-165 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13636

Entry ID Method Resolution Chain Position Source
AF-O13636-F1 Predicted AlphaFoldDB

No variants for O13636

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O13636

No associated diseases with O13636

1 regional properties for O13636

Type Name Position InterPro Accession
domain FCP1 homology domain 172 - 325 IPR004274

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLNRSLLFRN LRLARPRPFL PLVGKRFVTE KSQSQEEKDT SKITENAKEE VKRDTSSLAK
70 80 90 100 110 120
ESLKLLDLNG LNDESYTGDP GKGPEYTSST MLKREKQARY AFWGFLGLTG GGLLYYGRRY
130 140 150 160 170 180
GPDEKELEKQ YPAAGYSPSD WWNRVKARTN NFFSYYQEPA FEKLLPDPLP EPYNRPYTLV
190 200 210 220 230 240
LSLDDLLIHS EWTRQHGWRT AKRPGLDYFL GYLSMYYEVV IFTRQYLATA KPIIDKIDPY
250 260 270 280 290 300
HVSISAVLTR ESSKYEKGKV IKDLSYLNRD LSRVIMIDTN PESWSKQPDN AIAMAPWTGN
310 320 330 340 350 360
PKDKELVGLI PLLEFIAIMD IKDVRPVLKS YQGKNIPLEY ARREEKLRTK LIEDWNEKKK
370 380 390 400 410 420
KGSSFLFGGR SVSEEPPKLI IDIQRERQKA AYAEFKKYID ENGPKMLEEE KAREAEQKTS
430 440 450
IFNLLFHPEE VQQQQLEQMQ QQQFSPETNA SK