Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O13621
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O13621-F1 | Predicted | AlphaFoldDB |
No variants for O13621
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O13621 | |||||
No associated diseases with O13621
11 regional properties for O13621
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PB1 domain | 12 - 95 | IPR000270 |
| domain | Protein kinase domain | 253 - 522 | IPR000719 |
| domain | AGC-kinase, C-terminal | 524 - 595 | IPR000961 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 127 - 179 | IPR002219 |
| active_site | Serine/threonine-protein kinase, active site | 373 - 385 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 259 - 286 | IPR017441 |
| domain | Protein kinase, C-terminal | 544 - 585 | IPR017892 |
| domain | Diacylglycerol/phorbol-ester binding | 125 - 139 | IPR020454-1 |
| domain | Diacylglycerol/phorbol-ester binding | 141 - 150 | IPR020454-2 |
| domain | Diacylglycerol/phorbol-ester binding | 154 - 165 | IPR020454-3 |
| domain | Diacylglycerol/phorbol-ester binding | 166 - 178 | IPR020454-4 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cortical endoplasmic reticulum | A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chloride channel activity | Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| endoplasmic reticulum-plasma membrane tethering | The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNEKLQSYEK | QLTSDIVNNC | DLIIEVNASS | KTCQETLSSL | LRELQLSHFS | TAVRPGSDTS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IFVFVKVQND | YLIELAHNDR | TSSFLCGALD | DLNHVNVNSV | TDIDSSERIR | LVYDKITGSK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TEDSLGICPG | ENPYADIISI | FPLHQPKFDI | KWSKYWYQLL | LGNKKQLDSI | NAEYGSQVAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YFAFADFFKT | GVFVLSFWGI | LGYYFLRPYS | YIFAIGVALW | GAFFIQFWRV | QEHKLTNHWS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TVNCQSLAKS | MTEFKPQSYR | VDSLLGTARP | YYPQWEIIVR | STIANVPLFL | ISGCILLFLI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AIAFIVDVTL | SEVYSGPLKS | IVSLLPAVVF | QVLTLPFTFI | YSIVAERLTK | LENRRTKTDF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QASLSGKMFL | QNFMLSYTAL | FLISYIYGPF | AEYFVPHYIQ | NRMSQSFFSV | GYIAKSTFKL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NPLRLRNQYI | YFLTNAQVIN | YITILAVPQL | ISYVKKHYMS | KPTRELHIQD | IPSETVTLKR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ARSEAEKIEY | DCYNDYKDFV | LMFGFLVMFS | PIYPLAPIFS | LVNCVLYIRS | SVYRFTKMVK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KPVPCRVDSI | APWDQRLSLL | SWLGCITMPS | ICYFYSSTTK | PSDKSMVIAA | VIGLLSEHLW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FLLRMFISSV | FPVDKTFFAP | AKERQHLLAE | RSFSIPPVAD | VPTSTTTAFE | EADETLSIYR |
| TAENKKTK |