O13620
Gene name |
mrd1 (pi029, SPBP22H7.02c) |
Protein name |
Multiple RNA-binding domain-containing protein 1 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBP22H7.02c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O13620
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O13620-F1 | Predicted | AlphaFoldDB |
No variants for O13620
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O13620 | |||||
No associated diseases with O13620
6 regional properties for O13620
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 2 - 83 | IPR000504-1 |
| domain | RNA recognition motif domain | 323 - 401 | IPR000504-2 |
| domain | RNA recognition motif domain | 506 - 578 | IPR000504-3 |
| domain | RNA recognition motif domain | 619 - 702 | IPR000504-4 |
| domain | RNA recognition motif domain | 721 - 798 | IPR000504-5 |
| domain | Mrd1, RNA recognition motif 3 | 506 - 577 | IPR034482 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| 90S preribosome | A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
| small-subunit processome assembly | The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRIIIKNIP | RYYDKEKLST | YLKSLPQLDA | EITDVSVAKT | KEGVSRRFAF | IGFKNEEDAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KAIRYLNKSY | VETSRIEVHR | ALDYRSANEK | LRPYSKYASK | NIELKLQKKE | KEEELRNLEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKAKKKKDAN | LKRKFLDTLD | PKAREFLKLS | SSISNSRSWE | NEEVFDTEIT | NPVIPADEDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DEYQDLPAAK | RHEGDSIKST | EHDSTLDSGV | VIDGREKSSS | ELHEEESEQA | AEGDTAKNSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TDAQAPLSDD | EWLRLHRTRI | KEKQPEEEVS | VVGDELKSFD | KENNDEHLER | VTNDKIADAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MLQKAENNVS | EQERNIQLIS | ETKRLFLRNL | TYSCAEDDLK | SLFGPFGQLE | QVHMPIDKKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NNPKGFAYID | FHDADDAVRA | YLELDAKPFQ | GRLLHVLPAK | ARSSILLDDY | ALSKLPLKKQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RELKRKNTAA | SSTFSWNSLY | MNADAVVTSL | ASRLGVKKTD | ILDPTSSDSA | VKQALTETHV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IQETKNFFEE | HGVDLDAFKN | AARSDNVLLV | KNFPYGTSAE | ELTSLFSPFG | ELGRILIPPA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GTIAIIEFLN | APDCRQAFSK | LAYTRIKSSI | LYLEKAPRDV | FTTSFKQSGK | PELAQKVNAV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EATTSEKVGT | EDIESLDTAT | IYVKNLNFST | KQEEFQKVFK | PLEGYLSAVI | RAKPDPKRPG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KYLSMGFGFV | EFKDKASAVA | AMHAMNGFVL | DGHKLEIKLS | HQGVDAAAEV | RKQDSSKPKG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TKILIKNLPF | EATKKDVQSL | LGAYGQLRSV | RVPKKFDRSA | RGFAFAEFVT | AREAANAMRA |
| 790 | 800 | 810 | 820 | 830 | |
| LKNTHLLGRH | LVLQYASNAT | MDDMQHAIEK | MAKEANAEAA | APSITGKRLI | ETD |