O13134

PR
Gene name
SLC4A4 (NBC, NBCE1)
Protein name
Electrogenic sodium bicarbonate cotransporter 1
Names
Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4
Species
Ambystoma tigrinum (Eastern tiger salamander)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13134

Entry ID Method Resolution Chain Position Source
AF-O13134-F1 Predicted AlphaFoldDB

No variants for O13134

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O13134

No associated diseases with O13134

2 regional properties for O13134

Type Name Position InterPro Accession
domain Bicarbonate transporter-like, transmembrane domain 396 - 912 IPR011531
domain Band 3 cytoplasmic domain 95 - 344 IPR013769

Functions

Description
EC Number
Subcellular Localization
  • Basolateral cell membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
sodium:bicarbonate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
solute:inorganic anion antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSEKECLEN MLNGYAESGR VLSRTSLVIN QAVNRSIFTS TVSPAAERIR FILGEEDDSP
70 80 90 100 110 120
APPQLFTELD ELLAVDGQEM EWKETARWIK FEEKVEQGGE RWSKPHVATL SLHSLFELRT
130 140 150 160 170 180
CIEKGTILLD LEATSLPQIV EIVINNQIEL GLLKADMKEN VTRTLLRKHR HQTKKSNLRS
190 200 210 220 230 240
LADIGKTVSS ASRLFSTPDN GSPTMTHRNL TSTSLNDVSD KPDKEQLKNK FMKKLPRDAE
250 260 270 280 290 300
ASNVLVGEVD FLESPFIAFV RLQQAVMLGS LTEVPVPTRF LFILLGPKGK AKSYHEIGRS
310 320 330 340 350 360
IATLMSDEVF HDIAYKAKNR EDLIAGIDEF LDEVIVLPLG EWDPTIRIEP PKSLPSSDKR
370 380 390 400 410 420
KNMYSGGDNL QMNGDAPHDD GGGGHGDSEE LQRTGRFCGG LIKDIQRKAP FFASDFYDAL
430 440 450 460 470 480
SIQSLSAILF IYLGTVTNAI TFGGLLGDAT ENMQGVLESF LGTAVSGAVF CLFGGQPLTI
490 500 510 520 530 540
LSSTGPVLVF ERLLFNFSKD NDFDYLEFRL WIGLWSAFQC LILVATDASF LVKYFTRFTE
550 560 570 580 590 600
EGFSSLISFI FIYDAFKKMI KLADYYPINS HFKVDYITQY SCACFPPEPA NSSWFNMTTA
610 620 630 640 650 660
ATTTQFLTNA STDMAYNGTI DWSLLSKKEC LKYGGLLVGS NCKYVPDITL MSFILFLGTY
670 680 690 700 710 720
TCSMALKKFK TSRYFPTTAR KLISDFAIIL SILIFCGLDA LLGVDTPKLI VPSEFKPTSP
730 740 750 760 770 780
NRGWFVPPFG GNPWWVYLAA AIPALLVTIL IFMDQQITGV IVNRKEHKLK KGAGYHLDLF
790 800 810 820 830 840
WVAILMVVCS FMALPWYVAA TVISIAHIDS LKMETETSAP GEQPKFLGVR EQRVTGTVVF
850 860 870 880 890 900
LLTGLSVFMA PILKFIPMPV LYGVFLYMGV ASLNGVQFMD RLKLLLMPPK YQPDFIYLRH
910 920 930 940 950 960
VPLRRVHLFT FLQVVCLAML WILKSTVAAI IFPVMILALV AVRKAMDYFF SQHDLSFLDD
970 980 990 1000 1010 1020
VIPEKDKKKK EDEKKKKKKK GSIDSDVEDS DCPYPEKVPS IKIPMDIMEK EPFLIDSKPS
1030
DRENSPTFLE RHTSC