O13127

PR
Gene name
flot1
Protein name
Flotillin-1
Names
Reggie-2, REG-2
Species
Carassius auratus (Goldfish)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

143-420 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13127

Entry ID Method Resolution Chain Position Source
AF-O13127-F1 Predicted AlphaFoldDB

No variants for O13127

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O13127

No associated diseases with O13127

2 regional properties for O13127

Type Name Position InterPro Accession
domain Band 7 domain 5 - 266 IPR001107
domain Flotillin, C-terminal domain 310 - 389 IPR031905

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Endosome
  • Membrane, caveola ; Peripheral membrane protein
  • Melanosome
  • Membrane raft
  • Identified by mass spectrometry in melanosome fractions from stage I to stage IV
  • Membrane-associated protein of caveola
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endosome A vacuole to which materials ingested by endocytosis are delivered.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFYTCGPNEA MVVSGFCRSP PVMISGGSVF VFPCVQQIQR ISLNTLTLNV KSDKVYTRHG
70 80 90 100 110 120
VPVSVTGIAQ MKIQGQNKQM LAAKCQMFLG KSESDIAHIA LETLEGHQRA IIAHLTVEEI
130 140 150 160 170 180
YKDRKKFSEQ VFKVASSDLF NMGISVVSYT LKDVHDDQDY LHSLGKARTA QVQKDARIGE
190 200 210 220 230 240
AKNKRDAVIR EANAIQEKVS AQYMNEIEMA KAQRDYELKK AVYDIEVCTK KAESEMAYQL
250 260 270 280 290 300
QVAKTKQQIE EEKMQVMVVE RSQQIMLQEQ EIARKEKELE AQVMKPADAE RYRLEKLAEA
310 320 330 340 350 360
ERLQLIMEAE AEAESIKMRG EAEAYAVEAR GRAEAEQMAK KAEAFQTYKE GAMVDMLMEK
370 380 390 400 410 420
LPLIAEEISK PLSATNKVTM VSSGGSEIGA AKLTGEVLDI MTKLPETIEK LTGVSISQVA
RTG