O13022

PR
Gene name
dpysl3-a (dpysl3, nsp1)
Protein name
Dihydropyrimidinase-related protein 3-A
Names
DRP-3-A, Neural-specific protein 1
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:379803
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

479-564 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O13022

Entry ID Method Resolution Chain Position Source
AF-O13022-F1 Predicted AlphaFoldDB

No variants for O13022

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O13022

No associated diseases with O13022

1 regional properties for O13022

Type Name Position InterPro Accession
domain Amidohydrolase-related 64 - 453 IPR006680

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection, growth cone
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.

1 GO annotations of molecular function

Name Definition
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.

5 GO annotations of biological process

Name Definition
actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
positive regulation of filopodium assembly Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of neuron projection development Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
response to axon injury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYQGKKNIP RITSERLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI VPGGVKTIEA
70 80 90 100 110 120
NGKMVIPGGI DVHTHLQMPY RGMTTVDDFL QGTKAALAGG TTMIVDHVIP EPEASLTEAF
130 140 150 160 170 180
EKWREWADGK TCCDYSLHVD ITHWSDSVKQ EVETLVKQKG VNSFMVYMAY KDLYQMSNTE
190 200 210 220 230 240
LYEIFTFLGS LGAIAQVHAE NGDIIAQEQN RMLELGITGP EGHVLSRPEE LEAEAVFRAI
250 260 270 280 290 300
TIASQTNCPL YVTKVMSKSS VDLISQARKK GYVVFGEPIT ASLGTDGTHY WSKNWAKAAA
310 320 330 340 350 360
FVTSPPLSPD PTTPDYINSL LASGDLQVTG SAHATFSTAQ KAIGKDNFTL IPEGTNGIEE
370 380 390 400 410 420
RMSVIWDKSV ATGKMDENQF VSVTSTNAAK IFNLYPRKGR IAVGSDSDLV IWDPDAVKIV
430 440 450 460 470 480
SAKSHHSAAE YNIFEGMELR GAPLVVICQG KIMMEDGTLH VTQGTGRFIH CSPFPDYVYK
490 500 510 520 530 540
RIKARTKMAE LHGVPRGMYD GPVYDLASTP KAGTPAGSTK GSPTKQTPPV RNLHHSAFSL
550 560 570
AGNQGDESGV RSASRRIVAP PGGRSNITSL S