O09486

PR
Gene name
metK (sams)
Protein name
S-adenosylmethionine synthase
Names
AdoMet synthase, Methionine adenosyltransferase, MAT
Species
Amoeba proteus (Amoeba) (Chaos diffluens)
KEGG Pathway
EC number
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O09486

Entry ID Method Resolution Chain Position Source
AF-O09486-F1 Predicted AlphaFoldDB

No variants for O09486

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O09486

No associated diseases with O09486

5 regional properties for O09486

Type Name Position InterPro Accession
domain S-adenosylmethionine synthetase, N-terminal 7 - 107 IPR022628
domain S-adenosylmethionine synthetase, central domain 125 - 270 IPR022629
domain S-adenosylmethionine synthetase, C-terminal 280 - 420 IPR022630
conserved_site S-adenosylmethionine synthetase, conserved site 126 - 136 IPR022631-1
conserved_site S-adenosylmethionine synthetase, conserved site 306 - 314 IPR022631-2

Functions

Description
EC Number 2.5.1.6 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.

2 GO annotations of biological process

Name Definition
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
S-adenosylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQQNTRYLFA SEAVSRGHPD KACDQVSDRV LDYCLQAEKK CKKASRVALE TTIKGNVVGL
70 80 90 100 110 120
FGEVTCQKTF PTISWFRELV TEIGYSREDL DLDPTTCSVH INVRGQEAEI RGVVHNQERA
130 140 150 160 170 180
AKETLGAGDQ GLMFGYATDE TPERCPCLWF LLRRFKLALR SKFEEARKKK IELAVAKGIK
190 200 210 220 230 240
VSQVDATPEL RDTIDFWWLH TDAKSQVIIE YEDDSGALKP ITARVAVLSV QHSKFVTHDQ
250 260 270 280 290 300
YEDRLPQLVK GVLDEYGMHS EATEYLINIK QKTSGYGWTV GGPNADAGTT GRKIIVDTYG
310 320 330 340 350 360
GHGAHGGGAF SGKDPSKVDR SAAYYARYVA QNLVRAKLCR RVLVQVSYVI GKPEPLNIYV
370 380 390 400 410 420
NTYGTGTHSD SELLEIINKN FDFRPGFIIE ELDLLNPDRI KYVETAYHGH FGRPEFPWEQ
EKTLTL