AiPD: Autoinhibited Protein Database

Gene name	Man2b1 (Laman, Man2b, Manb)
Protein name	Lysosomal alpha-mannosidase
Names	Laman, Lysosomal acid alpha-mannosidase, Mannosidase alpha class 2B member 1, Mannosidase alpha-B
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:17159
EC number	3.2.1.24: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

558-627 (Predicted disordered autoinhibitory region) PR

558-627 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O09159-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs229798129	11	R>C	No	EVA
rs212026544	12	A>S	No	EVA
rs3388998427	15	G>A	No	EVA
rs3388979462	80	T>I	No	EVA
rs3398920797	90	S>G	No	EVA
rs3399443561	112	P>R	No	EVA
rs3389002283	115	R>L	No	EVA
rs239809986	133	S>N	No	EVA
rs3388998229	140	R>Q	No	EVA
rs3388998291	145	Q>L	No	EVA
rs3388990568	150	F>L	No	EVA
rs3388967466	167	A>T	No	EVA
rs3388998268	174	L>F	No	EVA
rs3388997951	201	S>Y	No	EVA
rs3388949202	212	G>S	No	EVA
rs3389002241	242	S>C	No	EVA
rs3388998020	242	S>R	No	EVA
rs3388991470	250	A>T	No	EVA
rs215544436	266	Y>D	No	EVA
rs230110066	291	T>K	No	EVA
rs3388973954	303	Q>L	No	EVA
rs3389002207	320	F>Y	No	EVA
rs3388985205	343	Q>H	No	EVA
rs13466172	344	V>A	No	EVA
rs3388993837	371	T>I	No	EVA
rs3388993885	372	V>M	No	EVA
rs51646694	434	A>T	No	EVA
rs3388985255	452	T>I	No	EVA
rs3388993893	470	G>E	No	EVA
rs3399443532	485	H>Y	No	EVA
rs238119812	541	H>Q	No	EVA
rs237885175	567	P>L	No	EVA
rs252251572	581	A>T	No	EVA
rs218288944	604	H>R	No	EVA
rs3388998029	644	W>G	No	EVA
rs212252889	653	E>K	No	EVA
rs212252889	653	E>Q	No	EVA
rs3388998009	666	N>K	No	EVA
rs3388993907	674	S>R	No	EVA
rs3388998266	697	W>C	No	EVA
rs3388973944	719	P>S	No	EVA
rs225699258	725	D>E	No	EVA
rs3388994868	734	F>I	No	EVA
rs13466173	750	G>D	No	EVA
rs3389003123	762	P>L	No	EVA
rs3388990552	806	Q>*	No	EVA
rs3388994892	810	L>F	No	EVA
rs3388991433	820	V>I	No	EVA
rs3388998326	826	V>M	No	EVA
rs3388998516	881	H>R	No	EVA
rs3388979465	919	E>K	No	EVA
rs3388997967	938	L>F	No	EVA
rs3388991472	953	Q>H	No	EVA
rs3389003169	959	A>S	No	EVA
rs13466169	980	Y>F	No	EVA

Type	Name	Position	InterPro Accession
domain	Glycoside hydrolase family 38, N-terminal domain	64 - 381	IPR000602
domain	Glycosyl hydrolase family 38, C-terminal	608 - 823	IPR011682
domain	Glycoside hydrolase family 38, central domain	386 - 483	IPR015341
domain	Glycosyl hydrolases family 38, C-terminal beta sandwich domain	901 - 1002	IPR041147

		Description
EC Number	3.2.1.24	Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization	Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
lysosomal lumen	The volume enclosed within the lysosomal membrane.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

Name	Definition
alpha-mannosidase activity	Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.
mannose binding	Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans.
metal ion binding	Binding to a metal ion.

Name	Definition
learning or memory	The acquisition and processing of information and/or the storage and retrieval of this information over time.
mannose metabolic process	The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
oligosaccharide catabolic process	The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.
protein modification process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins