O08782

PR
Gene name
AKR1B8
Protein name
Aldose reductase-related protein 2
Names
AR, Aldehyde reductase, Aldo-keto reductase
Species
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KEGG Pathway
cge:100689318
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for O08782

Entry ID Method Resolution Chain Position Source
1C9W X-ray 240 A A 2-316 PDB
AF-O08782-F1 Predicted AlphaFoldDB

No variants for O08782

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O08782

No associated diseases with O08782

4 regional properties for O08782

Type Name Position InterPro Accession
conserved_site Aldo/keto reductase, conserved site 39 - 56 IPR018170-1
conserved_site Aldo/keto reductase, conserved site 145 - 162 IPR018170-2
conserved_site Aldo/keto reductase, conserved site 261 - 276 IPR018170-3
domain NADP-dependent oxidoreductase domain 17 - 289 IPR023210

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
alditol:NADP+ 1-oxidoreductase activity Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTFVELSTK AKMPIVGLGT WQSPPGQVKE AVKVAIDAGY RHIDCAYAYY NEHEVGEAIQ
70 80 90 100 110 120
EKIKEKAVRR EDLFIVSKLW PTCFERKLLK EAFQKTLTDL KLDYLDLYLI HWPQGLQPGK
130 140 150 160 170 180
ELFPKDDQGN VLTSKITFLD AWEVMEELVD EGLVKALGVS NFNHFQIERI LNKPGLKHKP
190 200 210 220 230 240
VTNQVECHPY LTQEKLIEYC HSKGITVTAY SPLGSPNRPW AKPEDPSLLE DPKIKEIAAK
250 260 270 280 290 300
HKKTSAQVLI RFHIQRNVVV IPKSVTPARI HENFQVFDFQ LSDQEMATIL GFNRNWRACL
310
LPETVNMEEY PYDAEY