O08684
Gene name |
PLD1 |
Protein name |
Phospholipase D1 |
Names |
PLD 1, Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1 |
Species |
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) |
KEGG Pathway |
cge:100689404 |
EC number |
3.1.4.4: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08684
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08684-F1 | Predicted | AlphaFoldDB |
No variants for O08684
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O08684 | |||||
No associated diseases with O08684
5 regional properties for O08684
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phox homology | 79 - 212 | IPR001683 |
| domain | Phospholipase D/Transphosphatidylase | 459 - 486 | IPR001736-1 |
| domain | Phospholipase D/Transphosphatidylase | 853 - 880 | IPR001736-2 |
| domain | Pleckstrin homology domain | 220 - 330 | IPR001849 |
| domain | Phospholipase D-like domain | 729 - 898 | IPR025202 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.4 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| late endosome membrane | The lipid bilayer surrounding a late endosome. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| N-acylphosphatidylethanolamine-specific phospholipase D activity | Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| inositol lipid-mediated signaling | The series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. |
| lipid catabolic process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLKSEHRVN | TSALQKIAAD | MSNLIDNLDT | RELHFEGEEV | EFDTSPGDPK | AQEKYIPFSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IYNTQGFKEP | NIQTYLSGCP | IKAQVLEVER | FTSTTRVPSI | NLYTIELTHG | EFTWQVKRKF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KHFQEFHREL | LKYKAFIRIP | IPTKRHTFRR | QNVKEEPREM | PSLPRSSENT | IQEEQFFGRR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KQLEDYLTKI | LKMPMYRNYH | ATTEFLDVSQ | LSFIHDLGPK | GLEGMIMKRS | GGHRIPGLNC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CGQGRACYRW | SKRWLIVKDS | FLLYMKPDSG | AIAFVLLVDK | EFRIKVGRKE | TETKYGLRID |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NLSRTLILKC | NSYRHARWWG | GAIEEFIQKH | GSDFLKDHRF | GSYAAVHENM | LAKWYVNAKG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YFEDIANAME | EAAEEIFITD | WWLSPEIFLK | RPVVEGNRWR | LDCILKRKAQ | QGVRIFIMLY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KEVELALGIN | SEYSKRTLMR | LHPNIKVMRH | PDHVSSSVYL | WAHHEKLVII | DQSVAFVGGI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DLAYGRWDDN | EHRLTDVGSV | KRVTSGLSMG | SLAAATMESM | ESLSLKDNHR | SHKNEPILKS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VDDVDPKLKG | VGKPRKFSKF | SLYRQLHRRH | LHNSDSVSSI | DSASNTGSIR | SVQTGVGELH |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GETRFWHGKD | YCNFVFKDWV | QLDKPFADFI | DRYSTPRIPW | HDIGSVLHGK | AARDVARHFI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QRWNFTKIMK | PKYRSLSYPF | LLPKSQSTAH | ELRYQVPGAV | PAKVQLLRSA | ADWSAGIKHH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EESIHSAYIN | VIENSKHYIY | IENQFFISCA | DDKVVFNKVG | DAIAQRILKA | HREGQRYRVY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IVIPRLPGFE | GDISTGGGNA | LQAIMHFNYR | TMCRGENSIL | GQLKPELGNQ | WINYISFCGL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RTHAELEGNL | VTELIYVHSK | LLIADDNTVI | IGSANINDRS | MLGKRDSEMA | VIVQDTETVP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SIMDGKEYQA | GCFAQGLRLQ | CFRLVLGYLS | DPSEDLQDPV | SDKFFKEIWV | STAARNATIY |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DKVFRCLPND | EVHNLMQLRD | FISKPILAKD | DPIRAEEELR | KIRGFLVQFP | FYFLSEENLL |
| 1030 | |||||
| PSVGTKEAIV | PMEVWT |