O08451

PR
Gene name
acn
Protein name
Aconitate hydratase A
Names
ACN, Aconitase, (2R,3S)-2-methylisocitrate dehydratase, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase, Iron-responsive protein-like, IRP-like, Probable 2-methyl-cis-aconitate hydratase, RNA-binding protein
Species
Mycobacterium avium
KEGG Pathway
EC number
4.2.1.3: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O08451

Entry ID Method Resolution Chain Position Source
AF-O08451-F1 Predicted AlphaFoldDB

No variants for O08451

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O08451

No associated diseases with O08451

3 regional properties for O08451

Type Name Position InterPro Accession
domain DNA-binding HTH domain, TetR-type 10 - 70 IPR001647
domain Transcription regulator MAATS, C-terminal 84 - 202 IPR013572
conserved_site DNA-binding HTH domain, TetR-type, conserved site 28 - 58 IPR023772

Functions

Description
EC Number 4.2.1.3 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

7 GO annotations of molecular function

Name Definition
2-methylisocitrate dehydratase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O.
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
citrate dehydratase activity Catalysis of the reaction: citrate = cis-aconitate + H2O.
metal ion binding Binding to a metal ion.
mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

1 GO annotations of biological process

Name Definition
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQDKRTVKVG TVADTAVGGR TKSLGVEVTD SVNSFGARNR VKVGDKSYQI YRLDAVPNTE
70 80 90 100 110 120
KLPYSLKVLA ENLLRNEDGS NITKDHIEAI ANWDPKAGAS IEIQYTPARV VMQDFTGVPC
130 140 150 160 170 180
IVDLATMREA IADLGGNPEK VNPLAPADLV IDHSVIADLF GTADAFERNV EIEYQRNGER
190 200 210 220 230 240
YQFLRWLQGA FSDFKVVPPR RIVHQVNIEY LARVVMERVG VAYPDTCVGT DSHTTMVNGL
250 260 270 280 290 300
GVLGWGVGGI EAEAAMLGQP VSMLIPRVVG FKLTGEDPAP GAATDVVLTV TEICAKHGVV
310 320 330 340 350 360
GKFVEFYGEG VAEVPLANRA TLGNMSPEFG STAAIFPIDQ ETIDYLKFTG RNAEQVALVE
370 380 390 400 410 420
TYAKEQGLWH DPAHEPAFSE YLELDLSQVV PSIAGPKRPQ DRIALSQAKS VFREQIPSYV
430 440 450 460 470 480
GDGDGQQGYS KLDEVVDETF PASDPGAPSN GHADDLPAVQ SAAAHANGRP SNPVTVRSDE
490 500 510 520 530 540
LGEFVLDHGA VVIAAVTSCT NTSNPEVMLG AALLARQRVE KGLASKPWVK TTMAPGSQVV
550 560 570 580 590 600
HDYYDKAGLW PYLEKLGFYL VGYGCTTCIG NSGPLPEEIS KAINDNDLSV TAVLSGNRNF
610 620 630 640 650 660
EGRINPDVKM NYPASPPLVV AYALAGTMTR LEKQPLGKDK DGNDVYLKDI CRSQKTLGHH
670 680 690 700 710 720
PIGDNSEWFT KNYADVFKGE QAWRNLPTPT RNTFEWSPDS TYVRKPPYFE GMPAEPEPVA
730 740 750 760 770 780
DISSARVVAL LGDSVTTDHI SPAGSIKPGT PAAQYLDDAR RGPQGLQLFG CRRGNHEVMI
790 800 810 820 830 840
RGTFANIRLR NLLHDDVAGG YTRDFTQDGG PQAFIYDAAQ NYAAQNIPLV VLGGKEYGSG
850 860 870 880 890 900
SSRDWAAKGT RLLGVRAVIA ESFERIHRSN LIGMGVIPLQ FPDGKSAKDL GLDGTEVFDI
910 920 930 940 950 960
TGIEELNKGK TPKTVHVKAS KNGSDAAEFD AVVRIDTPGE ADYYRNGGIL QYVLRNMLKS
G