O08399

PR
Gene name
gyrB
Protein name
DNA gyrase subunit B
Names
Species
Treponema pallidum (strain Nichols)
KEGG Pathway
tpa:TP_1006
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

353-434 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O08399

Entry ID Method Resolution Chain Position Source
AF-O08399-F1 Predicted AlphaFoldDB

No variants for O08399

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O08399

No associated diseases with O08399

2 regional properties for O08399

Type Name Position InterPro Accession
domain IMP dehydrogenase/GMP reductase 8 - 317 IPR001093
conserved_site IMP dehydrogenase / GMP reductase, conserved site 166 - 178 IPR015875

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGIEYSASSI TVLEGLEAVR KRPGMYIGST GPNGLHHLVY EVVDNCIDEA MAGYCDRITV
70 80 90 100 110 120
VLEQGNVVRV EDNGRGIPVD VHPHEGVSAL EVVLTKLHAG GKFDKKSYKV SGGLHGVGVS
130 140 150 160 170 180
VVNALSLWVE VTVYRDGAEY YQKFNVGMPL APVEKRGVSE KRGTIIRWQA DPSIFKETVA
190 200 210 220 230 240
YDFDVLLTRL RELAFLNSTV VIQLRDERLA TAKQVEFAFE GGIRHFVSYL NRGKSVVPER
250 260 270 280 290 300
PLYIEGSKSD VLVEVALQYH DGYTENVQSF VNDINTREGG THLEGFKSAL TRVANDFLKK
310 320 330 340 350 360
SPKLAKKIER EEKLVGEDVR AGLTVVLSVK IPEPQFEGQT KTKLGNSEVR GIVDSLVGER
370 380 390 400 410 420
LTLYFEQNPG VLTKILEKSI AEAQARLAAR RAKEAARRKS GMDSFGLPGK LADCSLKDPA
430 440 450 460 470 480
KCEVYIVEGD SAGGSAKKGR DSKTQAILPL WGKMLNVEKT RLDKVLHNEK LQPIIATLGT
490 500 510 520 530 540
GVGKDFDLTR IRYHKVIIMA DADVDGSHIR TLLLTFFFRY LPQIIEAGYV YLAMPPLYRI
550 560 570 580 590 600
AWSKKELYVY SDTERDEALE SIGKKSGVAV QRYKGLGEMD GTQLWETTMN PVRRKMMQVV
610 620 630
LSDAVEADRV FSTLMGEDVE PRRKFIEENA IYARLDV