O07853
Gene name |
srp54 |
Protein name |
Signal recognition particle 54 kDa protein |
Names |
SRP54 |
Species |
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) |
KEGG Pathway |
sai:Saci_1310 |
EC number |
3.6.5.4: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O07853
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O07853-F1 | Predicted | AlphaFoldDB |
No variants for O07853
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O07853 | |||||
No associated diseases with O07853
4 regional properties for O07853
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Signal recognition particle, SRP54 subunit, GTPase domain | 95 - 292 | IPR000897 |
| domain | AAA+ ATPase domain | 94 - 297 | IPR003593 |
| domain | Signal recognition particle, SRP54 subunit, M-domain | 326 - 424 | IPR004125 |
| domain | Signal recognition particle SRP54, helical bundle | 1 - 81 | IPR013822 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.4 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| signal recognition particle | A complex of protein and RNA which facilitates translocation of proteins across membranes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7S RNA binding | Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| SRP-dependent cotranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLDGLRDAVR | KFLGSSDYEK | AVNEFIKELQ | IILIKADVNV | RLVKDLTDRI | KKRITEEKPP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SAIEKREWFI | SIVYDELSRL | FGGDKEPEVM | PKKLPYIIML | VGVQGSGKTT | TSGKLALFYK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KKGYKVGLVA | ADIYRPAAYE | QLIQIGQQIN | IPVYGEPGNK | NPIEIATNGL | EKFLKEKMNI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VIIDTAGRHG | YGEEASLLEE | MKSMYDKIHP | DEVILVIDAS | IGQKAYDLAS | RFHQASPIGS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LIVSKMDGTA | KGGGALSAVI | ATGAQIKFIG | TGEKLDELEV | FNPRRFVSRL | LGLGDIESII |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKIKSVEDYE | NLEKRMEDVI | SGKTKLTLRD | IYKQLIALRK | MGPLGKIFQM | LPGAGILSQV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEEQLKLGEE | KIRTFMAIMN | SMTYKELDNP | SIIDKARMRR | IAKGAGVTVE | EVKELLKQYQ |
| 430 | 440 | ||||
| MTNNLLKMVK | RRKGLAKLFG | GSNQ |