O07717
Gene name |
aceAb (Rv1916, RVBD_1916, LH57_10435, P425_01981) |
Protein name |
Putative isocitrate lyase subunit B |
Names |
ICL, Isocitrase, Isocitratase |
Species |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
KEGG Pathway |
mtv:RVBD_1916 |
EC number |
4.1.3.1: Oxo-acid-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for O07717
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 8G8K | X-ray | 154 A | A | 237-398 | PDB |
| AF-O07717-F1 | Predicted | AlphaFoldDB |
No variants for O07717
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O07717 | |||||
No associated diseases with O07717
No regional properties for O07717
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O07717 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.3.1 | Oxo-acid-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| isocitrate lyase activity | Catalysis of the reaction: isocitrate = glyoxylate + succinate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| carboxylic acid metabolic process | The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTYGEAVADV | LEFGQSEGEP | IGMAPEEWRA | FAARASLHAA | RAKAKELGAD | PPWDCELAKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PEGYYQIRGG | IPYAIAKSLA | AAPFADILWM | ETKTADLADA | RQFAEAIHAE | FPDQMLAYNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPSFNWDTTG | MTDEEMRRFP | EELGKMGFVF | NFITYGGHQI | DGVAAEEFAT | ALRQDGMLAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARLQRKMRLV | ESPYRTPQTL | VGGPRSDAAL | AASSGRTATT | KAMGKGSTQH | QHLVQTEVPR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLLEEWLAMW | SGHYQLKDKL | RVQLRPQRAG | SEVLELGIHG | ESDDKLANVI | FQPIQDRRGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TILLVRDQNT | FGAELRQKRL | MTLIHLWLVH | RFKAQAVHYV | TPTDDNLYQT | SKMKSHGIFT |
| 370 | 380 | 390 | |||
| EVNQEVGEII | VAEVNHPRIA | ELLTPDRVAL | RKLITKEA |