O06159

PR
Gene name
bkdC (pdhC, Rv2495c)
Protein name
Dihydrolipoyllysine-residue acyltransferase component of branched-chain alpha-ketoacid dehydrogenase complex
Names
Branched-chain alpha-ketoacid dehydrogenase complex component E2, BCKADH E2, Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv2495c
EC number
2.3.1.168: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

56-209 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for O06159

Entry ID Method Resolution Chain Position Source
3L60 X-ray 200 A A 154-393 PDB
6ZZN X-ray 150 A A 165-393 PDB
AF-O06159-F1 Predicted AlphaFoldDB

No variants for O06159

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O06159

No associated diseases with O06159

3 regional properties for O06159

Type Name Position InterPro Accession
domain Biotin/lipoyl attachment 7 - 82 IPR000089
domain 2-oxoacid dehydrogenase acyltransferase, catalytic domain 167 - 390 IPR001078
domain Peripheral subunit-binding domain 118 - 157 IPR004167

Functions

Description
EC Number 2.3.1.168 Transferring groups other than amino-acyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule.
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-dihydrolipoyl)lysine.
lipoic acid binding Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGEDSIRSF PVPDLGEGLQ EVTVTCWSVA VGDDVEINQT LCSVETAKAE VEIPSPYAGR
70 80 90 100 110 120
IVELGGAEGD VLKVGAELVR IDTGPTAVAQ PNGEGAVPTL VGYGADTAIE TSRRTSRPLA
130 140 150 160 170 180
APVVRKLAKE LAVDLAALQR GSGAGGVITR ADVLAAARGG VGAGPDVRPV HGVHARMAEK
190 200 210 220 230 240
MTLSHKEIPT AKASVEVICA ELLRLRDRFV SAAPEITPFA LTLRLLVIAL KHNVILNSTW
250 260 270 280 290 300
VDSGEGPQVH VHRGVHLGFG AATERGLLVP VVTDAQDKNT RELASRVAEL ITGAREGTLT
310 320 330 340 350 360
PAELRGSTFT VSNFGALGVD DGVPVINHPE AAILGLGAIK PRPVVVGGEV VARPTMTLTC
370 380 390
VFDHRVVDGA QVAQFMCELR DLIESPETAL LDL