O05706

PR
Gene name
dpo3
Protein name
DNA polymerase 3
Names
DNA polymerase B3, DNA polymerase III
Species
Saccharolobus shibatae (Sulfolobus shibatae)
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

635-708 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O05706

Entry ID Method Resolution Chain Position Source
AF-O05706-F1 Predicted AlphaFoldDB

No variants for O05706

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O05706

No associated diseases with O05706

3 regional properties for O05706

Type Name Position InterPro Accession
domain DNA-directed DNA polymerase, family B, exonuclease domain 27 - 300 IPR006133
domain DNA-directed DNA polymerase, family B, multifunctional domain 375 - 451 IPR006134-1
domain DNA-directed DNA polymerase, family B, multifunctional domain 551 - 736 IPR006134-2

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

1 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIKDFFILDF SYEIKDNIPL IYIWSIDDEG NSCVVVERNF KPYFYVVYEG NGDEIIENIR
70 80 90 100 110 120
KNCEVLLITK VKRKYLGNVV DALLVQTFTP TQIKRCREKI SRINGIKSIF DADIRFTMRY
130 140 150 160 170 180
SIDFDLRPFT WFKAEVSEVK LEGFRAKKVY ILDKILSHYE GKIPELRAIG IDFQIYSKYG
190 200 210 220 230 240
SLNPRKDPIV VLSLWSKEGS MQFSLDESMD DLKIIRKFVD YILNYDPDII YVFDVDVFHW
250 260 270 280 290 300
KYITERANSL GVKIDIGRKI GSEVSQGTYG HYSISGRLNV DLVGLLMNER LTGHIDLIEV
310 320 330 340 350 360
ANYLGISPKR DSLNWYEISR YWDDEKNRDL VKQYSLENAK SIYLLGNFLL SPYSELVKII
370 380 390 400 410 420
GLPLDKLSVA SWGNRIEASL IRTAAKSEEL IPIRMDNPNR SSKIKKTVIE PKIGIYSDVY
430 440 450 460 470 480
VLDISSVYLS VIRKFNISPD TLVKGQCDDC YVSTISNYKF KKEPSGLYKT FLEELSNIQD
490 500 510 520 530 540
TRKSKVIEEL MSSFYDYIHW INSRWYSREI ASAVDELSYE IGKLVIDLIK NSGFEVILAN
550 560 570 580 590 600
DFLVFVKGGS GDKLNELIFK INSLYDLNLK VRKIYRSLLI LGNDRYAGLL EGDKIDIARI
610 620 630 640 650 660
GKEDRDLCEL VRNVKRKVVE EILISKDVKK AVKLVKSAVI KLRRGEFDIG ELITWVHIEK
670 680 690 700 710 720
DFSEYDKQLP FVVAARKAIQ SGYLISKDSR IGYLIVKGHG SVHDRAEPFF FVKEKNRIDI
730 740 750 760
EYYVDQLLRE SLKVLTPLGV SEESLKKTNI TDILDMFGAS KKK