O05461

SS
Gene name
mycP1 (Rv3883c)
Protein name
Mycosin-1
Names
EC 3.4.21.- , MycP1 protease
Species
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
KEGG Pathway
mtu:Rv3883c
EC number
3.4.21.-: Serine endopeptidases
Protein Class

Descriptions

Mycosin-1 protease (MycP1) is a serine protease anchored to the inner membrane of Mycobacterium tuberculosis, and is essential in virulence factor secretion through the ESX-1 type VII secretion system (T7SS). MycP1's autoinhibition involves a putative propeptide that wraps around the protease domain in a non-classical manner. Although not directly inhibiting proteolytic activity, the propeptide contributes to conformational stability of the active site, influencing MycP1's function.

Autoinhibitory domains (AIDs)

24-62 (N-terminal inhibitory propeptide) SS

Target domain

64-387 (Protease domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O05461

Entry ID Method Resolution Chain Position Source
AF-O05461-F1 Predicted AlphaFoldDB

No variants for O05461

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O05461

No associated diseases with O05461

1 regional properties for O05461

Type Name Position InterPro Accession
domain Peptidase S8/S53 domain 81 - 379 IPR000209

Functions

Description
EC Number 3.4.21.- Serine endopeptidases
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
  • Cell wall-associated
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

4 GO annotations of biological process

Name Definition
modulation by symbiont of host process The process in which a symbiont organism effects a change in the structure or processes of its host organism.
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of secretion Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHRIFLITVA LALLTASPAS AITPPPIDPG ALPPDVTGPD QPTEQRVLCA SPTTLPGSGF
70 80 90 100 110 120
HDPPWSNTYL GVADAHKFAT GAGVTVAVID TGVDASPRVP AEPGGDFVDQ AGNGLSDCDA
130 140 150 160 170 180
HGTLTASIIA GRPAPTDGFV GVAPDARLLS LRQTSEAFEP VGSQANPNDP NATPAAGSIR
190 200 210 220 230 240
SLARAVVHAA NLGVGVINIS EAACYKVSRP IDETSLGASI DYAVNVKGVV VVVAAGNTGG
250 260 270 280 290 300
DCVQNPAPDP STPGDPRGWN NVQTVVTPAW YAPLVLSVGG IGQTGMPSSF SMHGPWVDVA
310 320 330 340 350 360
APAENIVALG DTGEPVNALQ GREGPVPIAG TSFAAAYVSG LAALLRQRFP DLTPAQIIHR
370 380 390 400 410 420
ITATARHPGG GVDDLVGAGV IDAVAALTWD IPPGPASAPY NVRRLPPPVV EPGPDRRPIT
430 440
AVALVAVGLT LALGLGALAR RALSRR