O04395

PR
Gene name
Protein name
Flavonol synthase/flavanone 3-hydroxylase
Names
FLS
Species
Matthiola incana (Common stock) (Cheiranthus incanus)
KEGG Pathway
EC number
1.14.11.9: With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

30-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O04395

Entry ID Method Resolution Chain Position Source
AF-O04395-F1 Predicted AlphaFoldDB

No variants for O04395

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O04395

No associated diseases with O04395

3 regional properties for O04395

Type Name Position InterPro Accession
domain Oxoglutarate/iron-dependent dioxygenase 151 - 250 IPR005123
domain Non-haem dioxygenase N-terminal domain 2 - 106 IPR026992
domain Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain 156 - 248 IPR044861

Functions

Description
EC Number 1.14.11.9 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
flavonol synthase activity Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O.
L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
metal ion binding Binding to a metal ion.
naringenin 3-dioxygenase activity Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
QVPVVDLSCP DEELVARTVV KASEDWGVFQ VVNHGIPTEL IQRLQKVGRE FFELPEAEKR
70 80 90 100 110 120
SCAREAGSVE GYGRRIELDI KKRKGIVDQI YLSTWPPSSV NYRYWPKSPP DYREVNEEYA
130 140 150 160 170 180
RHVKTLSEKI MEWLSEGLGL GREAIKEVNG CWYVMNINHY PPYPHSDSFN GLEPHTDING
190 200 210 220 230 240
LTLIITNEIP GLQVFKDDHW IEVEYIPSAI IVNIGDQIMM LSNGKYKNVL HKTTVDKEKT
250 260 270 280 290
RMSWPVLVSP TYDMVVGPLP ELTSEDDPPK FKPIAYKDYV HNKITFLKNK S