O04373
Gene name |
ILL4 |
Protein name |
IAA-amino acid hydrolase ILR1-like 4 |
Names |
jasmonoyl-L-amino acid hydrolase |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G51760 |
EC number |
3.5.1.127: In linear amides |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O04373
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O04373-F1 | Predicted | AlphaFoldDB |
35 variants for O04373
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH01346065 | 3 | F>L | No | 1000Genomes | |
| ENSVATH01346066 | 4 | F>C | No | 1000Genomes | |
| ENSVATH13509378 | 6 | W>L | No | 1000Genomes | |
| ENSVATH04935985 | 6 | W>R | No | 1000Genomes | |
| ENSVATH04935986 | 17 | N>T | No | 1000Genomes | |
| ENSVATH04935987 | 19 | T>S | No | 1000Genomes | |
| ENSVATH01346067 | 30 | Q>L | No | 1000Genomes | |
| ENSVATH04935989 | 43 | D>E | No | 1000Genomes | |
| ENSVATH01346068 | 43 | D>Y | No | 1000Genomes | |
| tmp_1_19199694_T_C | 45 | F>L | No | 1000Genomes | |
| tmp_1_19199695_T_C | 45 | F>S | No | 1000Genomes | |
| ENSVATH14289916 | 54 | R>G | No | 1000Genomes | |
| ENSVATH04935990 | 67 | E>Q | No | 1000Genomes | |
| tmp_1_19199790_G_A | 77 | E>K | No | 1000Genomes | |
| ENSVATH13509380 | 83 | Y>F | No | 1000Genomes | |
| tmp_1_19199823_G_A | 88 | A>T | No | 1000Genomes | |
| ENSVATH14289918 | 129 | G>R | No | 1000Genomes | |
| ENSVATH13509406 | 140 | T>A | No | 1000Genomes | |
| ENSVATH07644169 | 154 | E>V | No | 1000Genomes | |
| tmp_1_19200461_G_C | 173 | G>A | No | 1000Genomes | |
| ENSVATH01346115 | 182 | G>R | No | 1000Genomes | |
| tmp_1_19200495_G_C | 184 | L>F | No | 1000Genomes | |
| tmp_1_19200556_A_G | 205 | S>G | No | 1000Genomes | |
| ENSVATH04935995 | 223 | S>R | No | 1000Genomes | |
| tmp_1_19200649_A_T | 236 | I>L | No | 1000Genomes | |
| tmp_1_19200682_G_A | 247 | V>I | No | 1000Genomes | |
| tmp_1_19200848_T_C | 276 | F>S | No | 1000Genomes | |
| ENSVATH04935999 | 295 | K>E | No | 1000Genomes | |
| ENSVATH14289921 | 324 | I>V | No | 1000Genomes | |
| tmp_1_19201095_C_T | 332 | P>S | No | 1000Genomes | |
| ENSVATH01346127 | 354 | I>T | No | 1000Genomes | |
| tmp_1_19201237_A_T | 379 | H>L | No | 1000Genomes | |
| ENSVATH04936004 | 383 | V>A | No | 1000Genomes | |
| tmp_1_19201404_A_T | 435 | N>Y | No | 1000Genomes | |
| ENSVATH01346135 | 437 | K>R | No | 1000Genomes |
No associated diseases with O04373
1 regional properties for O04373
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Short-chain dehydrogenase/reductase, conserved site | 197 - 225 | IPR020904 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.1.127 | In linear amides |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum lumen | The volume enclosed by the membranes of the endoplasmic reticulum. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
| IAA-Ala conjugate hydrolase activity | Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine. |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin metabolic process | The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth. |
| response to wounding | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8H3C9 | ILL7 | IAA-amino acid hydrolase ILR1-like 7 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFFKWVSFV | LILHLLNPTL | ISCSSNGLSQ | IPSKFLTLAK | RNDFFDWMVG | IRRRIHENPE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGYEEVETSK | LVRAELEKMG | VSYKYPVAVT | GVVGYVGTGH | APFVALRADM | DALAMQEMVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WEHKSKVPGK | MHACGHDAHT | TMLLGAAKLL | KEHEEELQGT | VVLVFQPAEE | GGGGAKKIVE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AGVLENVSAI | FGLHVTNQLA | LGQVSSREGP | MLAGSGFFKA | KISGKGGHAA | LPQHTIDPIL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AASNVIVSLQ | HLVSREADPL | DSQVVTVAKF | EGGGAFNVIP | DSVTIGGTFR | AFSTKSFMQL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KKRIEQVITR | QASVNMCNAT | VDFIEEEKPF | FPPTVNDKAL | HQFFKNVSGD | MLGIENYVEM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QPLMGSEDFS | FYQQAIPGHF | SFVGMQNKAR | SPMASPHSPY | FEVNEELLPY | GASLHASMAT |
| 430 | |||||
| RYLLELKAST | LNKSNKKDEL |