O02822

PR
Gene name
KCNJ11 (KIR62)
Protein name
ATP-sensitive inward rectifier potassium channel 11
Names
Inward rectifier K(+) channel Kir6.2, Potassium channel, inwardly rectifying subfamily J member 11
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100008648
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O02822

Entry ID Method Resolution Chain Position Source
AF-O02822-F1 Predicted AlphaFoldDB

No variants for O02822

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O02822

No associated diseases with O02822

2 regional properties for O02822

Type Name Position InterPro Accession
domain Potassium channel, inwardly rectifying, transmembrane domain 36 - 173 IPR040445
domain Inward rectifier potassium channel, C-terminal 181 - 353 IPR041647

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
ATP-activated inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.

1 GO annotations of biological process

Name Definition
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSRKGIIPE EYVLTRLAED PAEPRYRARE RRARFVSKKG NCNVAHKNIR EQGRFLQDVF
70 80 90 100 110 120
TTLVDLKWTH TLLIFTMSFL CSWLLFAMVW WLIAFAHGDL APGEGAAVPC VTSIHSFSSA
130 140 150 160 170 180
FLFSIEVQVT IGFGGRMVTE ECPLAILILI VQNIVGLMIN AIMLGCIFMK TAQAHRRAET
190 200 210 220 230 240
LIFSKHAVIA LRQGRLCFML RVGDLRKSMI ISATIHMQVV RKTTSPEGEV VPLHQVDIPM
250 260 270 280 290 300
ENGVGGNSIF LVAPLIIHHV IDANSPLYDL APSDLHHHQD LEIIVILEGV VETTGITTQA
310 320 330 340 350 360
RTSYLADEIL WGQRFVPIVA EEDGRYSVDY SKFGNTVKVP TPLCTARQLD EDRSLLDALT
370 380
LTSARGPLRK RSVPVAKAKP KFSISPDSLS