O00939

PR
Gene name
Protein name
Telomerase reverse transcriptase
Names
Telomerase catalytic subunit, Telomerase subunit P123
Species
Euplotes aediculatus (Ciliate)
KEGG Pathway
EC number
2.7.7.49: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

618-689 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O00939

Entry ID Method Resolution Chain Position Source
AF-O00939-F1 Predicted AlphaFoldDB

No variants for O00939

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O00939

No associated diseases with O00939

7 regional properties for O00939

Type Name Position InterPro Accession
domain Dinoflagellate luciferase, N-terminal 1 - 83 IPR007959
domain Luciferase, helical bundle domain 112 - 178 IPR018475-1
domain Luciferase, helical bundle domain 490 - 555 IPR018475-2
domain Luciferase, helical bundle domain 867 - 931 IPR018475-3
domain Luciferase catalytic domain 191 - 486 IPR018804-1
domain Luciferase catalytic domain 568 - 863 IPR018804-2
domain Luciferase catalytic domain 944 - 1239 IPR018804-3

Functions

Description
EC Number 2.7.7.49 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
  • Chromosome, telomere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
metal ion binding Binding to a metal ion.
telomerase RNA reverse transcriptase activity Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEVDVDNQAD NHGIHSALKT CEEIKEAKTL YSWIQKVIRC RNQSQSHYKD LEDIKIFAQT
70 80 90 100 110 120
NIVATPRDYN EEDFKVIARK EVFSTGLMIE LIDKCLVELL SSSDVSDRQK LQCFGFQLKG
130 140 150 160 170 180
NQLAKTHLLT ALSTQKQYFF QDEWNQVRAM IGNELFRHLY TKYLIFQRTS EGTLVQFCGN
190 200 210 220 230 240
NVFDHLKVND KFDKKQKGGA ADMNEPRCCS TCKYNVKNEK DHFLNNINVP NWNNMKSRTR
250 260 270 280 290 300
IFYCTHFNRN NQFFKKHEFV SNKNNISAMD RAQTIFTNIF RFNRIRKKLK DKVIEKIAYM
310 320 330 340 350 360
LEKVKDFNFN YYLTKSCPLP ENWRERKQKI ENLINKTREE KSKYYEELFS YTTDNKCVTQ
370 380 390 400 410 420
FINEFFYNIL PKDFLTGRNR KNFQKKVKKY VELNKHELIH KNLLLEKINT REISWMQVET
430 440 450 460 470 480
SAKHFYYFDH ENIYVLWKLL RWIFEDLVVS LIRCFFYVTE QQKSYSKTYY YRKNIWDVIM
490 500 510 520 530 540
KMSIADLKKE TLAEVQEKEV EEWKKSLGFA PGKLRLIPKK TTFRPIMTFN KKIVNSDRKT
550 560 570 580 590 600
TKLTTNTKLL NSHLMLKTLK NRMFKDPFGF AVFNYDDVMK KYEEFVCKWK QVGQPKLFFA
610 620 630 640 650 660
TMDIEKCYDS VNREKLSTFL KTTKLLSSDF WIMTAQILKR KNNIVIDSKN FRKKEMKDYF
670 680 690 700 710 720
RQKFQKIALE GGQYPTLFSV LENEQNDLNA KKTLIVEAKQ RNYFKKDNLL QPVINICQYN
730 740 750 760 770 780
YINFNGKFYK QTKGIPQGLC VSSILSSFYY ATLEESSLGF LRDESMNPEN PNVNLLMRLT
790 800 810 820 830 840
DDYLLITTQE NNAVLFIEKL INVSRENGFK FNMKKLQTSF PLSPSKFAKY GMDSVEEQNI
850 860 870 880 890 900
VQDYCDWIGI SIDMKTLALM PNINLRIEGI LCTLNLNMQT KKASMWLKKK LKSFLMNNIT
910 920 930 940 950 960
HYFRKTITTE DFANKTLNKL FISGGYKYMQ CAKEYKDHFK KNLAMSSMID LEVSKIIYSV
970 980 990 1000 1010 1020
TRAFFKYLVC NIKDTIFGEE HYPDFFLSTL KHFIEIFSTK KYIFNRVCMI LKAKEAKLKS
1030
DQCQSLIQYD A