AiPD: Autoinhibited Protein Database

O00584

Gene name	RNASET2 (RNASE6PL)
Protein name	Ribonuclease T2
Names	CXC-R6, CXCR-6, CDw186, G-protein coupled receptor STRL33, G-protein coupled receptor bonzo, Ribonuclease 6
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8635
EC number	4.6.1.19: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

180-256 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

180-256 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for O00584

Entry ID	Method	Resolution	Chain	Position	Source
3T0O	X-ray	159 A	A	25-256	PDB
AF-O00584-F1	Predicted				AlphaFoldDB

257 variants for O00584

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000377846 rs886061241	1	M>missing	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinVar dbSNP
RCV001095751 CA151911997 rs911168436 CA366408504	8	G>R	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen TOPMed gnomAD ClinVar dbSNP
rs1583242286 RCV000000444	17	A>missing	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinVar dbSNP
RCV001196499 rs372273901 CA4095183 RCV001876274	44	P>L	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV001154608 CA4095108 RCV000960534 rs115956642	72	S>G	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000315978 CA10623422 rs886061240	75	C>Y	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP
rs1434250650 RCV001254880	78	S>*	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinVar dbSNP
CA4095054 RCV000277212 rs780445402	109	R>S	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV000331283 CA4095016 COSM207725 rs117003826	127	A>V	large_intestine Cystic leukoencephalopathy without megalencephaly [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA114257 VAR_063596 rs121918137 RCV000000440	184	C>R	Cystic leukoencephalopathy without megalencephaly LCWM; the loss of a disulfide bond may affect protein folding and stability; the protein is retained in the endoplasmic reticulum and the mitochondria while lysosomal localization is disrupted [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV001151596 rs759190975 CA4094867	188	S>I	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
RCV001344128 rs137968522 RCV002547003 CA4094836	204	T>A	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
RCV000439457 RCV000309087 CA4094831 rs41269593	215	E>K	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4094825 RCV000362169 rs202105909	218	E>K	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
COSM1582968 CA4094806 RCV000888819 RCV001157007 rs146590748	236	R>Q	Cystic leukoencephalopathy without megalencephaly meninges [ClinVar, Cosmic]	Yes	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000305139 rs11159 RCV001515723 VAR_013004 CA4094807	236	R>W	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs763295910 RCV000501289	238	L>missing	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinVar dbSNP
CA4094803 rs140357917 RCV000400857 RCV000892106	247	F>L	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs759625896 RCV001004878 CA4094800	250	P>S	Cystic leukoencephalopathy without megalencephaly [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1175946131 CA366408537	2	R>G		No	ClinGen TOPMed gnomAD
rs1175946131 CA366408536	2	R>S		No	ClinGen TOPMed gnomAD
CA366408527 rs1481833205	3	P>L		No	ClinGen gnomAD
CA4095208 rs748455635	3	P>S		No	ClinGen ExAC
rs1233809644 CA366408526	4	A>T		No	ClinGen gnomAD
rs1460580760 CA366408518	5	A>D		No	ClinGen gnomAD
rs778738197 CA366408519	5	A>P		No	ClinGen ExAC TOPMed gnomAD
rs778738197 CA4095207	5	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1224852048 CA366408512	6	L>P		No	ClinGen gnomAD
rs1396968925 CA366408499	9	A>T		No	ClinGen TOPMed
CA366408496 rs1309064255	9	A>V		No	ClinGen TOPMed
CA366408485 rs1330045184	11	L>P		No	ClinGen Ensembl
CA366408476 rs1452254618	13	C>R		No	ClinGen gnomAD
rs1404148222 CA366408467	14	L>F		No	ClinGen gnomAD
CA366408460 rs1466640652	15	C>Y		No	ClinGen gnomAD
rs1157636131 CA366408451	16	L>R		No	ClinGen gnomAD
rs1381369582 CA366408447	17	A>V		No	ClinGen gnomAD
CA366408433 rs1183333234	19	L>P		No	ClinGen gnomAD
TCGA novel	19	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1311705015 CA366408427	20	C>S		No	ClinGen TOPMed
CA151911979 rs62436422	21	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs62436422 CA366408423	21	L>V		No	ClinGen gnomAD
CA366408417 rs1240909002	22	G>C		No	ClinGen gnomAD
rs767378195 CA4095201	23	G>A		No	ClinGen ExAC gnomAD
rs767378195 CA366408410	23	G>D		No	ClinGen ExAC gnomAD
CA366408408 rs1483293081	24	A>T		No	ClinGen gnomAD
rs761630857 CA4095200	24	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1484231577 CA366408397	25	D>E		No	ClinGen TOPMed
rs1318633889 CA366408391	26	K>R		No	ClinGen gnomAD
CA366408384 rs1219282301	27	R>H		No	ClinGen Ensembl
CA366408386 rs1183952977	27	R>S		No	ClinGen TOPMed
rs371907141 CA4095196	28	L>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs903854377 CA151911921	29	R>C		No	ClinGen TOPMed gnomAD
rs768898749 CA366408345	31	N>K		No	ClinGen ExAC TOPMed gnomAD
rs779460565 CA4095188	31	N>S		No	ClinGen ExAC gnomAD
CA4095185 rs375297629	32	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs542520182 CA4095186	32	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA151908216 TCGA novel rs928399690	34	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen Ensembl
rs1268218510	36	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	37	L>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4095184 rs755657092	39	M>I		No	ClinGen ExAC TOPMed gnomAD
rs1164177909 CA366408291	39	M>L		No	ClinGen gnomAD
rs1372179117 CA366408282	40	V>A		No	ClinGen gnomAD
CA151908187 rs867764276	43	W>L		No	ClinGen Ensembl
TCGA novel	45	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774446299 CA151908170	46	T>A		No	ClinGen Ensembl
CA366408232 rs1478525897	47	V>G		No	ClinGen gnomAD
rs1467494028 CA366408237	47	V>I		No	ClinGen TOPMed gnomAD
rs1467494028 CA366408235	47	V>L		No	ClinGen TOPMed gnomAD
CA366408231 rs919595149	48	C>G		No	ClinGen TOPMed gnomAD
CA151908164 rs919595149	48	C>R		No	ClinGen TOPMed gnomAD
CA366408230 rs919595149	48	C>S		No	ClinGen TOPMed gnomAD
rs781133215 CA366408225	48	C>W		No	ClinGen ExAC TOPMed gnomAD
rs757238716 CA4095181 COSM1642948	49	E>K	stomach [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs750669368 CA4095156	52	Q>*		No	ClinGen ExAC gnomAD
rs761924699 CA366408070	54	D>H		No	ClinGen ExAC TOPMed gnomAD
CA4095154 rs761924699	54	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1258289810 CA366408014	58	P>L		No	ClinGen TOPMed
rs1424507603 CA366408010	59	P>A		No	ClinGen TOPMed
rs561514741 CA4095153	59	P>L		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	62	W>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs993184078 CA151904151	63	T>K		No	ClinGen TOPMed gnomAD
rs993184078 CA366407959	63	T>R		No	ClinGen TOPMed gnomAD
rs763394312 CA4095151	65	H>R		No	ClinGen ExAC gnomAD
rs1242789738 CA366407929 COSM3410784	68	W>*	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1278713421 CA366407906	69	P>L		No	ClinGen gnomAD
CA4095109 rs754155291	70	D>N		No	ClinGen ExAC TOPMed gnomAD
rs760285467 CA4095106	74	G>E		No	ClinGen ExAC gnomAD
rs760285467 CA151902266	74	G>V		No	ClinGen ExAC gnomAD
rs1253547373 CA366407864	76	N>D		No	ClinGen TOPMed
rs1178939961 CA366407861	76	N>S		No	ClinGen gnomAD
TCGA novel	77	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1434250650 CA366407844	78	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs771496431 CA4095104	79	W>L		No	ClinGen ExAC gnomAD
CA366407817 rs1441873284	82	N>S		No	ClinGen TOPMed gnomAD
CA4095103 rs761320310	83	L>*		No	ClinGen ExAC
CA366407812 rs1239628395	83	L>I		No	ClinGen TOPMed gnomAD
rs1239628395 CA366407813	83	L>V		No	ClinGen TOPMed gnomAD
rs1198825632 CA366407807	84	E>K		No	ClinGen gnomAD
TCGA novel	85	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4095100 rs749214203	85	E>G		No	ClinGen ExAC TOPMed gnomAD
CA4095101 rs768664056	85	E>K		No	ClinGen ExAC gnomAD
rs768664056 CA4095102	85	E>Q		No	ClinGen ExAC gnomAD
CA4095099 rs780031338	86	I>V		No	ClinGen ExAC gnomAD
rs769621975 CA4095098	87	K>*		No	ClinGen ExAC gnomAD
CA366407788 rs769621975	87	K>E		No	ClinGen ExAC gnomAD
CA366407094 rs1387040789	88	D>Y		No	ClinGen gnomAD
TCGA novel	89	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751250162 CA4095065	92	E>G		No	ClinGen ExAC gnomAD
rs987564260 CA151898075	93	M>T		No	ClinGen TOPMed
TCGA novel	94	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1249286606 CA366407044	95	A>V		No	ClinGen TOPMed
CA366407038 rs1280410103	96	Y>C		No	ClinGen gnomAD
CA4095064 rs763751033	96	Y>H		No	ClinGen ExAC gnomAD
CA4095062 rs367656044	97	W>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA4095063 rs762498853	97	W>R		No	ClinGen ExAC gnomAD
CA4095061 rs772187999	99	D>E		No	ClinGen ExAC gnomAD
CA4095059 rs529169150	100	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201959434 CA4095058	103	S>L		No	ClinGen 1000Genomes ExAC gnomAD
CA366406973 rs1326095554	106	N>H		No	ClinGen TOPMed gnomAD
rs993877408 CA366406971	106	N>I		No	ClinGen TOPMed gnomAD
CA151898039 rs993877408	106	N>S		No	ClinGen TOPMed gnomAD
CA4095056 rs774543357	107	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4095055 rs149426644	107	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA366406962 rs1199281718	108	S>C		No	ClinGen gnomAD
CA4095053 rs780445402	109	R>C		No	ClinGen ExAC TOPMed gnomAD
CA4095052 rs374162593	109	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs931339513 CA151894654	111	W>*		No	ClinGen TOPMed
CA366406912 rs1362425214	113	H>P		No	ClinGen TOPMed
CA366406900 rs1421687402	115	W>R		No	ClinGen TOPMed
CA4095026 rs754432508	116	E>K		No	ClinGen ExAC TOPMed gnomAD
CA4095024 rs763195467	118	H>P		No	ClinGen ExAC TOPMed gnomAD
rs1285213280 CA366406866	119	G>R		No	ClinGen gnomAD
CA4095020 rs763299296	122	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769927092 CA4095018	123	A>T		No	ClinGen ExAC TOPMed gnomAD
CA366406770 rs1562497492	126	D>G		No	ClinGen Ensembl
CA151894596 rs117003826	127	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA366406729 COSM1672970 rs1286334837	129	N>K	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1299915529 CA366406719	130	S>Y		No	ClinGen gnomAD
rs781239107	133	K>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs778325234 CA4095013	133	K>T		No	ClinGen ExAC gnomAD
TCGA novel	134	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366406279 rs1418731772	135	F>C		No	ClinGen gnomAD
CA4095010 rs747895403	137	R>G		No	ClinGen ExAC gnomAD
rs1476861062 CA366406255	137	R>K		No	ClinGen gnomAD
CA151894537 rs1031105313	138	S>N		No	ClinGen Ensembl
rs1208036022 CA366406234	139	L>P		No	ClinGen TOPMed
CA366406237 rs1426418231	139	L>V		No	ClinGen gnomAD
CA4095009 rs778373009	140	E>K		No	ClinGen ExAC gnomAD
rs200217470 CA4095008	141	L>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs779517174 CA4095006	141	L>R		No	ClinGen ExAC gnomAD
rs200217470 CA4095007	141	L>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756083307 CA4095005	142	Y>H		No	ClinGen ExAC gnomAD
CA151894514 rs977121991	145	L>R		No	ClinGen TOPMed
rs968384342 CA151894507	146	D>Y		No	ClinGen TOPMed gnomAD
TCGA novel	147	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200521055 CA151894500	149	S>I		No	ClinGen 1000Genomes
CA4094904 rs771231451	150	V>L		No	ClinGen ExAC TOPMed gnomAD
rs771231451 CA4094903	150	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1281450125 CA366409787	151	L>F		No	ClinGen gnomAD
CA4094901 rs564700188	152	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA366409778 rs564700188	152	L>R		No	ClinGen 1000Genomes ExAC gnomAD
CA366409752 rs1240582231	156	I>R		No	ClinGen gnomAD
rs758461719 CA4094900	158	P>A		No	ClinGen ExAC gnomAD
rs1394189622 CA366409731	159	S>F		No	ClinGen gnomAD
rs199674368 CA366409719	161	N>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199674368 COSM3697668 CA4094897	161	N>S	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA366409702 rs1190588643	163	Y>*		No	ClinGen TOPMed
rs1418823672 CA366409700	164	Q>K		No	ClinGen gnomAD
CA366409524 rs1244167002	165	V>F		No	ClinGen TOPMed gnomAD
rs1244167002 CA366409527	165	V>I		No	ClinGen TOPMed gnomAD
CA366409500 rs1233095538	167	D>E		No	ClinGen TOPMed gnomAD
rs756845295 CA4094874	167	D>G		No	ClinGen ExAC TOPMed gnomAD
CA151950134 rs867548038	168	F>C		No	ClinGen Ensembl
CA366409497 rs1447243603	168	F>L		No	ClinGen gnomAD
rs1211284477 CA366409485	169	K>E		No	ClinGen gnomAD
rs1298997016 CA366409480	169	K>I		No	ClinGen TOPMed
rs1273796776 CA366409470	170	D>G		No	ClinGen gnomAD
CA366409474 rs1336225419	170	D>H		No	ClinGen TOPMed gnomAD
TCGA novel	170	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366409458 rs1217929196	171	A>G		No	ClinGen gnomAD
CA366409452 rs1359654764	172	L>F		No	ClinGen gnomAD
TCGA novel	172	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs937734336 COSM1075930 CA151950123	173	A>T	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA366409432 rs1330770810	174	R>T		No	ClinGen gnomAD
rs1562493291 CA366409420	175	V>A		No	ClinGen Ensembl
rs1315470043 CA366409425	175	V>I		No	ClinGen TOPMed
CA4094872 rs763663043	177	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1395310183 CA366409391	178	V>A		No	ClinGen gnomAD
CA366409395 rs1239284254	178	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA366409375 rs1468475059	180	P>S		No	ClinGen TOPMed
CA366409328 rs930821082	184	C>*		No	ClinGen gnomAD
CA151950083 rs930821082	184	C>W		No	ClinGen gnomAD
rs752566896 CA4094870	185	L>F		No	ClinGen ExAC TOPMed gnomAD
rs752566896 CA366409326	185	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1434152025 CA366409304	187	P>R		No	ClinGen TOPMed
CA4094868 rs759190975	188	S>T		No	ClinGen ExAC TOPMed gnomAD
CA366409285 rs1245786090	189	Q>R		No	ClinGen gnomAD
rs774496285 CA4094841	193	V>I		No	ClinGen ExAC gnomAD
rs764236556 CA151949056	194	Q>H		No	ClinGen ExAC gnomAD
CA366408940 rs1360372731	196	I>T		No	ClinGen TOPMed
CA4094839 rs762901010	197	G>D		No	ClinGen ExAC TOPMed gnomAD
CA151949046 rs926185419	198	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA366408921 rs1175562744	199	I>T		No	ClinGen TOPMed gnomAD
CA151949039 rs974396478	200	E>D		No	ClinGen TOPMed gnomAD
rs776087270 CA4094837	201	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	203	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	204	T>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366408870 rs1583212057	207	D>A		No	ClinGen Ensembl
CA4094835 rs746342225	207	D>Y		No	ClinGen ExAC gnomAD
rs373290604 CA151949025	208	Q>R		No	ClinGen ESP TOPMed
CA366408821 rs777199814	214	T>A		No	ClinGen ExAC TOPMed gnomAD
CA4094834 rs777199814	214	T>P		No	ClinGen ExAC TOPMed gnomAD
rs41269593 CA4094832	215	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4094829 rs200901770	216	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4094830 rs200901770	216	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4094826 rs753772218	217	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA366408801 rs202105909	218	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4094824 rs755838611	218	E>V		No	ClinGen ExAC gnomAD
CA366408795 rs1354145190	219	Q>E		No	ClinGen gnomAD
CA366408783 rs751838276	220	P>L		No	ClinGen ExAC gnomAD
CA4094823 rs751838276	220	P>Q		No	ClinGen ExAC gnomAD
rs35716361 CA4094821	221	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA366408781 rs1583211964	221	S>P		No	ClinGen Ensembl
CA4094820 rs35716361 RCV000884362	221	S>Y		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs765400725 CA4094819	222	P>S		No	ClinGen ExAC TOPMed gnomAD
rs149106779 CA366408769	223	K>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs149106779 CA4094817	223	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs149106779 CA366408770	223	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA4094816 rs145013301	227	W>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA366408736 rs1415604749	228	L>M		No	ClinGen TOPMed gnomAD
TCGA novel	228	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1244702124 CA366408719	230	N>K		No	ClinGen TOPMed
CA366408710 rs1583211909	232	A>P		No	ClinGen Ensembl
CA151948909 rs1047556452	233	A>G		No	ClinGen TOPMed gnomAD
rs149922066 CA4094814	233	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000956442 rs149922066 CA4094813	233	A>T		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4094810 rs754474033	234	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs199823417 CA4094809	235	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA366408682 rs1340354301	237	G>A		No	ClinGen gnomAD
CA4094805 rs767307679	237	G>C		No	ClinGen ExAC TOPMed gnomAD
CA366408675 rs1583211839	239	R>G		No	ClinGen Ensembl
CA151948846 rs539299924	242	E>G		No	ClinGen Ensembl
TCGA novel	244	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	244	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA366408630 rs1363644149	245	P>L		No	ClinGen gnomAD
CA366408616 rs1296660279	247	F>C		No	ClinGen TOPMed
CA151948803 rs765446788	248	Y>S		No	ClinGen Ensembl
CA366408602 rs1391650191	249	P>L		No	ClinGen gnomAD
rs754430788 CA366408599	250	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA4094799 rs754430788	250	P>R		No	ClinGen ExAC TOPMed gnomAD
rs934916857 CA151948764	251	P>S		No	ClinGen gnomAD
rs1430007208 CA366408572	254	T>S		No	ClinGen gnomAD
CA4094798 rs766947293	255	K>R		No	ClinGen ExAC gnomAD
rs1455677556 CA366408563	256	H>N		No	ClinGen gnomAD
rs773490411 CA4094796	256	H>R		No	ClinGen ExAC TOPMed gnomAD
rs1230977284 CA366408549	257	H>C		No	ClinGen TOPMed
rs1230977284 CA366408550	257	H>W		No	ClinGen TOPMed

No associated diseases with O00584

6 regional properties for O00584

Type	Name	Position	InterPro Accession
conserved_site	ATP-dependent RNA helicase DEAD-box, conserved site	270 - 278	IPR000629
domain	Helicase, C-terminal	336 - 498	IPR001650
domain	DEAD/DEAH box helicase domain	135 - 313	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	130 - 340	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	111 - 139	IPR014014
domain	DDX52/Rok1, DEAD-box helicase domain	122 - 328	IPR044764

Functions

		Description
EC Number	4.6.1.19	Phosphorus-oxygen lyases
Subcellular Localization	Secreted Lysosome lumen Endoplasmic reticulum lumen Mitochondrion intermembrane space	Full-length RNASET2 is found in the endoplasmic reticulum while smaller RNASET2 proteolytic products are found in the lysosome fraction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
azurophil granule lumen	The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
lysosomal lumen	The volume enclosed within the lysosomal membrane.
lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
mitochondrial intermembrane space	The region between the inner and outer lipid bilayers of the mitochondrial envelope.

4 GO annotations of molecular function

Name	Definition
endoribonuclease activity	Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
ribonuclease activity	Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
ribonuclease T2 activity	Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates.
RNA binding	Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name	Definition
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
RNA catabolic process	The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MRPAALRGAL	LGCLCLALLC	LGGADKRLRD	NHEWKKLIMV	QHWPETVCEK	IQNDCRDPPD
70	80	90	100	110	120
YWTIHGLWPD	KSEGCNRSWP	FNLEEIKDLL	PEMRAYWPDV	IHSFPNRSRF	WKHEWEKHGT
130	140	150	160	170	180
CAAQVDALNS	QKKYFGRSLE	LYRELDLNSV	LLKLGIKPSI	NYYQVADFKD	ALARVYGVIP
190	200	210	220	230	240
KIQCLPPSQD	EEVQTIGQIE	LCLTKQDQQL	QNCTEPGEQP	SPKQEVWLAN	GAAESRGLRV
250
CEDGPVFYPP	PKKTKH