M9MSG8

PR
Gene name
Piezo
Protein name
Piezo-type mechanosensitive ion channel component
Names
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG44122
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

115-222 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for M9MSG8

Entry ID Method Resolution Chain Position Source
AF-M9MSG8-F1 Predicted AlphaFoldDB

No variants for M9MSG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for M9MSG8

No associated diseases with M9MSG8

2 regional properties for M9MSG8

Type Name Position InterPro Accession
domain Piezo non-specific cation channel, R-Ras-binding domain 2089 - 2519 IPR031334
domain Piezo domain 1226 - 1426 IPR031805

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H5I5 PIEZO2 Piezo-type mechanosensitive ion channel component 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MVFSYACMVL QRIVVPAVLV LAALMRPVGI SFVYLLMFFV SPFVPLATRR NFKGSVTAFF
70 80 90 100 110 120
IILLTLSTLV LLGHITLQIL AVSLTLPIYN CSFSERLLRH IGFVSFIDLQ PFAIIEWLVP
130 140 150 160 170 180
EVLVFATSLG SYLTVKRVAS QPVGAEQLEN GEVVDGQAEN AQTSSQPSAA DANGGDVQQA
190 200 210 220 230 240
TVTTPLQQQQ QQLRKRVSMI SQHIHFEGLV KISPLFCLAT LFFAAVLRPS VPGGFYFLIF
250 260 270 280 290 300
LLSGTYWATC QTLQRGFALL LRCVMVVLVL HSLSIVSYQT PWMQSHLNHT TLTARLIGLE
310 320 330 340 350 360
PLIESYCSPD IRVFLYNNKL SLDSYLNPFA LFFAYFALAL TTKHLIKPRL VRQSTRKART
370 380 390 400 410 420
PQPLESGSSV APSVTQRGND MQLESMEQRS EQENTTTSIL DQISYGFVSV GGFIYQNSYI
430 440 450 460 470 480
FTNILMMAWS IVYHSWLTFV LLLSANVLWM IPNQRKAMMR SSPFIVLYAE ALLIAQYIYG
490 500 510 520 530 540
MDLNNEELPT SVPTAGINLQ QIGFERPIEN QMRPCVPLIV KTAFVLMFWV TSRQFFKEKR
550 560 570 580 590 600
DRRRDSTLAD FIAPLQITVG SAGSSYLIND GKKTSKFLKK AGDVIKNLLV RLWIWLLVLV
610 620 630 640 650 660
IFLCAITGEN MTGFRICYMA LFLFFLLVFQ SSSKAWVKIM YGFWLFLIFY AMSILILIYT
670 680 690 700 710 720
YQFDKFDTYW SDYLNVSATL QKDIGLKRYQ TKDLFLHLVS PTIIVILTVI QVHYFHKRFI
730 740 750 760 770 780
ASLQQQPLAG GSAQQKPTET TALEPAPSKR RGSAGSLRKS QGPSAEAAPG ATTDFETSVR
790 800 810 820 830 840
DLVRISFRKI KNKSEYIFKN FKDVFWRFLE LHIMKAVYIA AFVCSVSEVC VLHIIFVGFC
850 860 870 880 890 900
VLGATSRKAV QVVISRLISF IVTVIVLSKM IYQIEYLSHS QHNVVCSDNR TANNAEWIGL
910 920 930 940 950 960
TKADKVTGGL MSLLRTYIIY MVIVTMHAVI SLRQLQMRVK IGALNAPPTK LLFPNIIRAD
970 980 990 1000 1010 1020
AEKDLVGLVK YLLNFGFYKF GIEISLIALV STITYRQDIV AVVYALWLVV LLLLRRSQCA
1030 1040 1050 1060 1070 1080
KIWGVFQAFF AISILTQYIV LVGLPPSSCL VFPWDEGPFG EGIQRWAMLP GALHFNHVPK
1090 1100 1110 1120 1130 1140
LIFDFIVLVI LNRQKSIFCI EQRYASNDDY PGGSNRSVIA DIAQLGRVPF DNPTHDFCSY
1150 1160 1170 1180 1190 1200
IRNYSDILKN GVLCGFYWFT LAVVFLAGTN IADLLALGYL IGAFIFLWQG SDFYLRPIHT
1210 1220 1230 1240 1250 1260
IIFRWKWLLA FNVANILIKT SFQMAGCLFM TQLTKDCCWL VHMLGITCTS NVLTEQIMLP
1270 1280 1290 1300 1310 1320
EEAELALKPG ECPKITHQVV LLWDTICFAF IIFQLRIFKS HYFCHIITDT KANNILASRG
1330 1340 1350 1360 1370 1380
ADIIESLRHK QIAHRHDHEK QVLHKIKRKM ERIRATQQKM LRPLDKQTHF DEHGYPLPAP
1390 1400 1410 1420 1430 1440
TVRRRKEIKL HPHATRAGDY YMFEEMDDKF ELDLIHDEID FLEEENITES EMKMQRRKTL
1450 1460 1470 1480 1490 1500
YDKSKDAPTG EFPSTSKGIS KERDAATASS SASPAPTRDV GDLPVIPPPS TGLGREQTSK
1510 1520 1530 1540 1550 1560
ETSDSKSKME VDSGEVTAKD SDEDFDTNPI IRLLEGFLVT LTIRLNRFSR NYRFVNRILA
1570 1580 1590 1600 1610 1620
GEKKTLKESS SLNRLGLSSA AAMFHFLKSN LESDESEPPA SSSTPRRVVI APPNATEHSD
1630 1640 1650 1660 1670 1680
PTSTTLNTNT TTTPLSPPEP LQPLQPLQPN TTSTPQQQHQ HIRAAEEIIE LPVDTVDGVA
1690 1700 1710 1720 1730 1740
HRKQSINSSP PAKGAGEFNL EEENFAQRDH HIIVEVLISS WYALLANTDL ICYIVVFINQ
1750 1760 1770 1780 1790 1800
VVNASLISLP LPIMVFLWGT LSLPRPTKTF WVTLIAYTQA IVLIKCIFQF KLIWSNYHQL
1810 1820 1830 1840 1850 1860
PNQPLTPAKI FGVENKAHYA IYDLILLLVL FLHRYLLKSQ GLWKSGYKDT DNQFTKPTAS
1870 1880 1890 1900 1910 1920
IDERDDSDNL SQPDSRQLND DAAQKLSLQV SQASLPGSPE FSKTGINQLE RTKYTSSLYK
1930 1940 1950 1960 1970 1980
FFFSLVHKSR LATDVYALMF LCDFVNFFVL LFGFTAFGTQ QTESDEGVQT YLAENKVPIP
1990 2000 2010 2020 2030 2040
FLIMLLVQFL LIVIDRALYL RKALVNKIIF HFFSVIGIHI WMFFVVPAVT ERTFNSLAPP
2050 2060 2070 2080 2090 2100
IIFYVIKCFY MLLSSYQIKS GYPKRILGNF FTKGFSMVNM IAFKVYMQIP FLYELRTILD
2110 2120 2130 2140 2150 2160
WVCIDSTMTI FDWLKMEDIF SNIYLIRCTR QSETDFPAMR AQKKASLSKL IMGGTIVLLI
2170 2180 2190 2200 2210 2220
VICIWGPLCL FALGNAVGTS NVPFHVSLSI RIGPYDPIYT TNNYDSIFEI NPEMYSQMTN
2230 2240 2250 2260 2270 2280
AYIKEKQALT FIAGYDATDV AAVRLAGNSP SLWNIAPPDR QRLLNDLRNN HTLKARFSYS
2290 2300 2310 2320 2330 2340
LTRKAPAKGL KENVGDEHAI SLDESFEGRA ALIHMLSETH DVEPIYSNGT TNGTTPEVEE
2350 2360 2370 2380 2390 2400
VVVIPGMIPK FIKVLNSGDA AVVSVLSPKH YDYRPLVIKM HRDNETNGLW WEIRDYCNDT
2410 2420 2430 2440 2450 2460
FYNETLSKFA YSNCTSGIVM YTFNDKKFPS TFSFLTAGGI IGLYTTFVLL ASRFMKSFIG
2470 2480 2490 2500 2510 2520
GQNRKIMFED LPYVDRVLQL CLDIYLVREA LEFALEEDLF AKLLFLYRSP ETLIKWTRPK
2530 2540 2550
EEYVDDDGDT DSIPSRMSVR RPEQLQPQQP Q