J3S6Y1

PR
Gene name
Tspear
Protein name
Thrombospondin-type laminin G domain and EAR repeat-containing protein
Names
TSP-EAR
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:252974
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

221-299 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for J3S6Y1

Entry ID Method Resolution Chain Position Source
AF-J3S6Y1-F1 Predicted AlphaFoldDB

30 variants for J3S6Y1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs223206865 3 A>V No EVA
rs1135114984 19 R>C No EVA
rs236530449 54 V>A No EVA
rs3389107085 57 V>M No EVA
rs3389097094 58 R>G No EVA
rs3389097094 58 R>W No EVA
rs3389107123 66 E>* No EVA
rs3389115506 79 S>A No EVA
rs221744504 83 F>L No EVA
rs3401454897 165 V>G No EVA
rs213402038 191 T>N No EVA
rs3389077001 203 S>N No EVA
rs3389111368 206 R>G No EVA
rs3389102285 209 G>A No EVA
rs3389052726 243 I>T No EVA
rs247525787 245 Q>R No EVA
rs3389097041 248 K>* No EVA
rs263331605 249 R>K No EVA
rs235517904 251 T>P No EVA
rs254141835 261 N>K No EVA
rs3389077035 274 S>T No EVA
rs3389108320 285 Q>H No EVA
rs3389108268 290 A>D No EVA
rs3389111337 384 K>N No EVA
rs231098951 397 R>K No EVA
rs3389109351 450 H>L No EVA
rs3389119622 488 Y>F No EVA
rs3389120158 545 N>D No EVA
rs3401361434 570 N>S No EVA
rs3389087605 630 V>A No EVA

No associated diseases with J3S6Y1

2 regional properties for J3S6Y1

Type Name Position InterPro Accession
domain ABC1 atypical kinase-like domain 93 - 344 IPR004147
domain UbiB domain, bacteria 93 - 344 IPR045308

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Cell surface
  • Cell projection, stereocilium
  • Secreted protein which may bind to the cell surface via a membrane receptor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9D454 Uncharacterized protein CXorf49 homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MSALLMLCAV LLLLGTPSRG ARPWEPCTDL RPLDILAEVV PLNGATSGIR MVQVEGVRGL
70 80 90 100 110 120
QFSATEPRTT SFPASRIFSS CDFFPEEFSI IVTLRVPNLP PKKNEYLLSL LAEERDTLLL
130 140 150 160 170 180
GLRYSPTQLH FLFLSEDLAG AWQTRVSFWS PGLMDSRWHT LILAVSQGSF SLTTDCGLPV
190 200 210 220 230 240
DIMADVSFPP TLSVRGARFF IGSRKRTKGL FTGVIRQLVL LPGSDATPQL CPSRNARLAE
250 260 270 280 290 300
LSIPQVLKRL TGKPDDNEVL NYPYEADMKV TLGSRPPCTK AEGAQFWFDA AQKGLYLCAG
310 320 330 340 350 360
SEWVSVLAAK TKLDYVEEHQ SLHTNSETLG IEVFSIPGVG LFAAAANRKA RSAIYKWTDG
370 380 390 400 410 420
KFVSYQNIAT HQAQSWRHFT IGKKIFLAVA NFGPNERGQE FSVIYKWSPR KLKFTLYQRI
430 440 450 460 470 480
ATHSARDWEA FEVDGEHFLV VANHREGDNH NIDSMVYRWN PSSQLFEANQ SIATSGAYDW
490 500 510 520 530 540
EFFTVGPYSF LVVANTFNGT STQVHSHLYI WLVGAFQLFQ SFLTFGAADW EVFHIGERIF
550 560 570 580 590 600
LAVANSHSYD VQMQAQNDSY VLSSVIYELN ITAQTFVKFQ DIPTCSALDW EFFSVGEDHF
610 620 630 640 650 660
LVVANSFDGN TFSVNSIIYR WQGYEGFVAV HKLPTFGCRD WEAFNTTAGS YLIYSSAKEP
LSRVLKLRTG