H8F0D6
Gene name |
ERDMAN_1266 |
Protein name |
2-methylcitrate dehydratase |
Names |
2-MC dehydratase, Aconitate hydratase, ACN, Aconitase |
Species |
Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) |
KEGG Pathway |
mtn:ERDMAN_1266 |
EC number |
4.2.1.3: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for H8F0D6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-H8F0D6-F1 | Predicted | AlphaFoldDB |
No variants for H8F0D6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for H8F0D6 | |||||
No associated diseases with H8F0D6
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.3 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2-methylcitrate dehydratase activity | Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O. |
| aconitate hydratase activity | Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. |
| citrate dehydratase activity | Catalysis of the reaction: citrate = cis-aconitate + H2O. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| propionate metabolic process, methylcitrate cycle | The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle. |
| tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVRIMLMHAV | RAWRSADDFP | CTEHMAYKIA | QVAADPVDVD | PEVADMVCNR | IIDNAAVSAA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SMVRRPVTVA | RHQALAHPVR | HGAKVFGVEG | SYSADWAAWA | NGVAARELDF | HDTFLAADYS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HPADNIPPLV | AVAQQLGVCG | AELIRGLVTA | YEIHIDLTRG | ICLHEHKIDH | VAHLGPAVAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GIGTMLRLDQ | ETIYHAIGQA | LHLTTSTRQS | RKGAISSWKA | FAPAHAGKVG | IEAVDRAMRG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EGSPAPIWEG | EDGVIAWLLA | GPEHTYRVPL | PAPGEPKRAI | LDSYTKQHSA | EYQSQAPIDL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ACRLRERIGD | LDQIASIVLH | TSHHTHVVIG | TGSGDPQKFD | PDASRETLDH | SLPYIFAVAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QDGCWHHERS | YAPERARRSD | TVALWHKIST | VEDPEWTRRY | HCADPAKKAF | GARAEVTLHS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GEVIVDELAV | ADAHPLGTRP | FERKQYVEKF | TELADGVVEP | VEQQRFLAVV | ESLADLESGA |
| 490 | 500 | ||||
| VGGLNVLVDP | RVLDKAPVIP | PGIFR |