H2LRU7

PR
Gene name
pkd2
Protein name
Polycystin-2
Names
Polycystic kidney disease 2 protein homolog
Species
Oryzias latipes (Japanese rice fish) (Japanese killifish)
KEGG Pathway
ola:100192346
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for H2LRU7

Entry ID Method Resolution Chain Position Source
AF-H2LRU7-F1 Predicted AlphaFoldDB

No variants for H2LRU7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for H2LRU7

No associated diseases with H2LRU7

4 regional properties for H2LRU7

Type Name Position InterPro Accession
domain Cryptochrome/DNA photolyase, FAD-binding domain 241 - 395 IPR005101
domain DNA photolyase, N-terminal 2 - 153 IPR006050
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 290 - 302 IPR018394-1
conserved_site Cryptochrome/DNA photolyase class 1, conserved site, C-terminal 310 - 329 IPR018394-2

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium membrane ; Multi-pass membrane protein
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Cell membrane ; Multi-pass membrane protein
  • Basolateral cell membrane
  • Cytoplasmic vesicle membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cation channel complex An ion channel complex through which cations pass.
ciliary membrane The portion of the plasma membrane surrounding a cilium.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

9 GO annotations of molecular function

Name Definition
calcium channel activity Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
calcium ion binding Binding to a calcium ion (Ca2+).
cation channel activity Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
muscle alpha-actinin binding Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc.
outward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force.
potassium channel activity Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

12 GO annotations of biological process

Name Definition
calcium ion transmembrane transport A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
cell-cell signaling by wnt Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell.
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
detection of mechanical stimulus The series of events by which a mechanical stimulus is received and converted into a molecular signal.
detection of nodal flow The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.
inorganic cation transmembrane transport A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other.
protein heterotetramerization The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
regulation of ion transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.
release of sequestered calcium ion into cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSATRVRPQS QAGTDKPPRT LDSSEGIEME NIQHQDPGLG GVAGSPSPPS RQAWSRDNPV
70 80 90 100 110 120
FEPEEEIMQA DWPQASPGRR SAFTASGGSS CSSGHGGYTR AGSSTQIPRG GLYPTQTLNG
130 140 150 160 170 180
QQQDRHEHPG CMKRIFQNIR ILWGTELMED GDSNRERYLW NVLRELLTYI AFLITICILT
190 200 210 220 230 240
YGMISTNMYY YTKAMSQLFL DAPLSSENPK TFRSLSTMED FWKYTQGPFL GGMYWEVWYN
250 260 270 280 290 300
NQSLPGNQSF IYYENILLGV PRLRQVRVHN ETCSIHEDLR DEVQGCYGVY TPSNEDNSPF
310 320 330 340 350 360
GPQNGTAWVH TTESKMNAST HWGQVSKYGG GGYYQDLSRT REESGLQLQF LKDHLWLDRG
370 380 390 400 410 420
TRAIFLDFSV YNGNVNLVCI ARLLVEFPAT GGVLTSWQFQ TLRLIKYVSS WDYFVGVCEV
430 440 450 460 470 480
AFCLFVLYYV VEEVLEIHIH RLHYFKNLWN CLDVLIVTLS VVAIIMSITR AAMGGDLLKG
490 500 510 520 530 540
LENYTSHTSF DSLANLQVQF NNMAAVIVFF CWVKLFKFIN FNKTMSQLST TMSRCAKDLV
550 560 570 580 590 600
GFAIMFFIIF LAYAQLAYLV FGTQVNDFST FQGSVFTQFR IILGDFDFFE IKEANPVLGP
610 620 630 640 650 660
IYFITFVLFI FFILMNMFLA IINDTYSEVK ADMAQHRSEM EMTDFIKKGC TKALVKLRLK
670 680 690 700 710 720
KTTVDDISDS LRQAGGKLNY DELLQDLKEK GHTEAEIQAI FAKYDQDGDL ELTEHDHQQM
730 740 750 760 770 780
RDDLEKERED LDLERNSLTR PSSGRSFPRT QDDSEEDDDE DSGHSSRRRG SSSGGVSYEE
790 800 810 820 830 840
FQVLVRRVDR MEHSIGSIVS KIDAVIVKLE GMERAKLKRR DVLVRLLDGV MEDERLGRDA
850 860 870 880 890 900
DTHREQMERL VKEELERWET DDVASQVSHP QPATPIGPRP RPPSSLSTDG LDTSANGGTH
V