G9NNY7

PR
Gene name
mcl
Protein name
2-methylisocitrate lyase, mitochondrial
Names
Species
Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma atroviride)
KEGG Pathway
EC number
4.1.3.30: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for G9NNY7

Entry ID Method Resolution Chain Position Source
AF-G9NNY7-F1 Predicted AlphaFoldDB

No variants for G9NNY7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for G9NNY7

No associated diseases with G9NNY7

2 regional properties for G9NNY7

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 226 - 231 IPR018523
domain ICL/PEPM domain 86 - 497 IPR039556

Functions

Description
EC Number 4.1.3.30 Oxo-acid-lyases
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.

1 GO annotations of biological process

Name Definition
carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAASAPSNSL PPADSYQLLP EAQKAGAAED ALYEAQVKEI EEWWASPRFA GIRRPYSAAD
70 80 90 100 110 120
VASKRGSQHF RYPSSVMATK LFNLIREREA KGEPIHTMGA IDPVQMTQQA PHQEVLYISG
130 140 150 160 170 180
WACSSVLTST NEVSPDFGDY PYNTVPNQVQ RLAKAQSMHD RKQWDTRRKM SPDERSKTPY
190 200 210 220 230 240
TDYLRPIIAD GDTGHGGLSA VLKLAKLFAE NGAAAVHFED QLHGGKKCGH LAGKVLVPTG
250 260 270 280 290 300
EHINRLNAAR FQWDVMGSEN LVIARTDSES GRLISSAIDV RDHEFILGIA DPAVEPLAET
310 320 330 340 350 360
LQSMEARGAT GAEIDVFEAK WVKSSTLVTF DEAAVAHMKK EGVSQAKIDE YLSATALDRD
370 380 390 400 410 420
MGISRRRALA SQFTETPVYF NWDVPRTREG YYHFRAGMEA ATKRALAFAP YADLLWVETG
430 440 450 460 470 480
DPNVEVAAKL GRAVRSVNPG KSLVYNLSPS FNWMAHGFSE EGLKSFIWDI AKEGFTLQLI
490 500 510 520 530 540
SLAGLHSTAT ITNELAKKFK TDGMKAYVEV VQRREKELGC DVLTHQKWSG ASYIDGILGA
550 560
IQSGNSSSRS MGEGNTEGQF D