G5EDT6

PR
Gene name
jkk-1
Protein name
Dual specificity mitogen-activated protein kinase kinase jkk-1
Names
MAP kinase kinase jkk-1, JNK-1 activator kinase, JNK kinase
Species
Caenorhabditis elegans
KEGG Pathway
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-141 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

263-285 (Activation loop from InterPro)

Target domain

122-385 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for G5EDT6

Entry ID Method Resolution Chain Position Source
AF-G5EDT6-F1 Predicted AlphaFoldDB

No variants for G5EDT6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for G5EDT6

No associated diseases with G5EDT6

2 regional properties for G5EDT6

Type Name Position InterPro Accession
domain Protein kinase domain 122 - 385 IPR000719
active_site Serine/threonine-protein kinase, active site 242 - 254 IPR008271

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
  • Cytoplasm
  • Perikaryon
  • Cell projection, axon
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
JUN kinase kinase activity Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

5 GO annotations of biological process

Name Definition
hyperosmotic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
locomotion Self-propelled movement of a cell or organism from one location to another.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
stress-activated MAPK cascade The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9X2 MAP2K6 Dual specificity mitogen-activated protein kinase kinase 6 Bos taurus (Bovine) EV
O14733 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens (Human) PR
P46734 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 Homo sapiens (Human) SS
P45985 MAP2K4 Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens (Human) EV
Q8CE90 Map2k7 Dual specificity mitogen-activated protein kinase kinase 7 Mus musculus (Mouse) PR
P70236 Map2k6 Dual specificity mitogen-activated protein kinase kinase 6 Mus musculus (Mouse) EV
P47809 Map2k4 Dual specificity mitogen-activated protein kinase kinase 4 Mus musculus (Mouse) EV
O09110 Map2k3 Dual specificity mitogen-activated protein kinase kinase 3 Mus musculus (Mouse) PR
Q4KSH7 Map2k7 Dual specificity mitogen-activated protein kinase kinase 7 Rattus norvegicus (Rat) PR
G5EDF7 sek-1 Dual specificity mitogen-activated protein kinase kinase sek-1 Caenorhabditis elegans PR
Q10664 mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 Caenorhabditis elegans PR
Q21307 mek-1 Dual specificity mitogen-activated protein kinase kinase mek-1 Caenorhabditis elegans PR
Q9DGE0 map2k6 Dual specificity mitogen-activated protein kinase kinase 6 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MENVCFQQRL RDLETRVRKW KFLKLGLTEV RLRPRDRRST SVDQKHKECS STSSSPQHQR
70 80 90 100 110 120
PNNIGYLTSP MERKFTPLSM KPSPSRRDTE KDALEYEFLE GYKKSGTLEI DGEKQVVDPN
130 140 150 160 170 180
EIHIISLLGS GSCGVVESAT VRSKLMAVKT MYKNDNKENL KRILRDVRIM SMCNSPFIVT
190 200 210 220 230 240
SYGYFMFDSS VKICMQIMSA CCEKLLRRIY HSKLDFFPEF VAGHIVYSAI SALDYLKEKH
250 260 270 280 290 300
SIIHRDIKPS NILFDDSGNV KLCDFGISGF MTDSMAHSKS AGCPPYMAPE RLTIETNSKY
310 320 330 340 350 360
DVRSDVWSLG ITVYQLVTGL YPFPLNDMEF TTLTIIANLN LPSPSLREET KRSFSPLFIE
370 380 390 400 410 420
FLDLCLRKDV RERPEYRQLM KHDFYLDYDP ASGSAYKFKA INGKCNQVAD WFVDVIRLSK
430
TEDELKSIPN TPCVN