G5ECJ0
PR
Gene name |
exp-1 |
Protein name |
Gamma-aminobutyric acid receptor exp-1 |
Names |
Expulsion defective protein 3, GABA(A) receptor |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_H35N03.1 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for G5ECJ0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G5ECJ0-F1 | Predicted | AlphaFoldDB |
No variants for G5ECJ0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for G5ECJ0 | |||||
No associated diseases with G5ECJ0
3 regional properties for G5ECJ0
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| excitatory extracellular ligand-gated ion channel activity | Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. |
| GABA receptor activity | Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. |
| neurotransmitter receptor activity | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. |
| transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. |
11 GO annotations of biological process
| Name | Definition |
|---|---|
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| defecation | The expulsion of feces from the rectum. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| lipid transport involved in lipid storage | The directed movement of lipids into cells that is part of their accumulation and maintenance. |
| nervous system process | A organ system process carried out by any of the organs or tissues of neurological system. |
| positive regulation of intestinal lipid absorption | Any process that activates or increases the frequency, rate or extent of intestinal lipid absorption. |
| positive regulation of muscle contraction | Any process that activates or increases the frequency, rate or extent of muscle contraction. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of membrane potential | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| sodium ion transport | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O14764 | GABRD | Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (Human) | PR |
| Q9UN88 | GABRQ | Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (Human) | PR |
| P22933 | Gabrd | Gamma-aminobutyric acid receptor subunit delta | Mus musculus (Mouse) | PR |
| Q09453 | ggr-1 | Glycine receptor subunit beta-type 4 | Caenorhabditis elegans | PR |
| Q17328 | glc-2 | Glutamate-gated chloride channel subunit beta | Caenorhabditis elegans | PR |
| P41849 | lgc-50 | Ligand-gated ion channel 50 | Caenorhabditis elegans | PR |
| P54244 | deg-3 | Acetylcholine receptor subunit alpha-type deg-3 | Caenorhabditis elegans | PR |
| P54246 | acr-5 | Acetylcholine receptor subunit alpha-type acr-5 | Caenorhabditis elegans | PR |
| Q93149 | acr-3 | Acetylcholine receptor subunit beta-type acr-3 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASILILAT | CHQVLADFNS | YVVPQPHAQR | DHRQDISQHY | DYLMEENDEP | LGRGAAPSKY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSSHGQAQHR | PEMTESENFA | QPNTESVFSS | GGVDSYGETR | DFLQFLRRIQ | YDHRQVPENE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KGEATYVEVS | VVVSNIRAVS | EVTMDYALEL | FYRESWRDPR | LQYDRKLFKN | KTELALHESY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TNFLWFPDTF | VPNAIASKNP | QRNSISHRSL | LRLDETGKLL | YSRRISLVCE | CTMDLTLFPF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DKQLCKLGIE | SYGYTADHVV | YKWSKGARTA | LELKKIRLPD | FTIQEAYVTS | QMESYATGNY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SRLYVCFVFS | RSSGFCFLQL | IIPSTAVVIT | SWVSLWMETE | TEFQDMISII | LAITFLIFSY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NEMMPRVSYI | KAMDIYLGVC | FMIVFLSLIK | LALVKYMRQK | IMLTSDSGNS | LREMSQMSTR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QRLRARKTSN | MNFRNNGGGS | IPINEEHQQM | LTVPNGEDKM | ANGDDKEANN | NGKSHLSDML |
| 490 | 500 | 510 | 520 | 530 | |
| EIRITQRTMH | RFHWISQMLF | FFGFVIFCLF | YFLIYPNLHI | VSVDPACDKN | LAEWFADIY |