G3UYX5
PR
Gene name |
Rgs22 |
Protein name |
Regulator of G-protein signaling 22 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:626596 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for G3UYX5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-G3UYX5-F1 | Predicted | AlphaFoldDB |
64 variants for G3UYX5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389364227 | 21 | Y>* | No | EVA | |
| rs3389352539 | 66 | K>R | No | EVA | |
| rs3389351318 | 82 | Y>F | No | EVA | |
| rs3389359921 | 86 | R>S | No | EVA | |
| rs3389356842 | 154 | S>N | No | EVA | |
| rs3389278588 | 164 | N>Y | No | EVA | |
| rs3389328241 | 181 | T>A | No | EVA | |
| rs3389372925 | 211 | A>G | No | EVA | |
| rs3389358698 | 218 | V>A | No | EVA | |
| rs248318860 | 220 | M>L | No | EVA | |
| rs223265334 | 223 | L>F | No | EVA | |
| rs3389347506 | 228 | P>T | No | EVA | |
| rs32303299 | 256 | L>P | No | EVA | |
| rs254465488 | 259 | S>T | No | EVA | |
| rs3389328163 | 274 | I>V | No | EVA | |
| rs240471037 | 287 | V>I | No | EVA | |
| rs32264007 | 290 | E>Q | No | EVA | |
| rs240987163 | 293 | G>D | No | EVA | |
| rs258587109 | 293 | G>S | No | EVA | |
| rs222576748 | 294 | G>E | No | EVA | |
| rs251918341 | 300 | T>I | No | EVA | |
| rs229831136 | 312 | A>T | No | EVA | |
| rs244446265 | 344 | H>R | No | EVA | |
| rs252377791 | 387 | I>V | No | EVA | |
| rs3389358673 | 427 | W>R | No | EVA | |
| rs3389372866 | 464 | L>F | No | EVA | |
| rs3405963391 | 496 | L>Q | No | EVA | |
| rs3389352482 | 525 | R>H | No | EVA | |
| rs261850926 | 563 | N>D | No | EVA | |
| rs258806690 | 587 | E>D | No | EVA | |
| rs3389364196 | 604 | K>M | No | EVA | |
| rs3389328195 | 685 | K>N | No | EVA | |
| rs3389338946 | 710 | K>* | No | EVA | |
| rs51139442 | 733 | L>H | No | EVA | |
| rs1133844250 | 760 | I>N | No | EVA | |
| rs3389351378 | 762 | L>I | No | EVA | |
| rs3405951729 | 788 | T>A | No | EVA | |
| rs3404481080 | 788 | T>S | No | EVA | |
| rs3389309526 | 803 | H>L | No | EVA | |
| rs51486807 | 807 | I>L | No | EVA | |
| rs51486807 | 807 | I>V | No | EVA | |
| rs253808075 | 821 | K>T | No | EVA | |
| rs3389328237 | 840 | G>V | No | EVA | |
| rs3406089069 | 865 | S>E | No | EVA | |
| rs227774992 | 885 | I>V | No | EVA | |
| rs3389328167 | 895 | K>Q | No | EVA | |
| rs3405963389 | 908 | Y>* | No | EVA | |
| rs3405959131 | 908 | Y>C | No | EVA | |
| rs3389347494 | 925 | M>L | No | EVA | |
| rs3389320341 | 931 | W>* | No | EVA | |
| rs3389367497 | 959 | W>* | No | EVA | |
| rs247746421 | 1080 | Y>C | No | EVA | |
| rs3389372882 | 1101 | R>SE* | No | EVA | |
| rs3389338930 | 1102 | K>R | No | EVA | |
| rs3389328182 | 1104 | L>M | No | EVA | |
| rs1134010790 | 1125 | P>T | No | EVA | |
| rs3389278585 | 1126 | Q>L | No | EVA | |
| rs224963098 | 1158 | T>I | No | EVA | |
| rs3389338942 | 1178 | L>H | No | EVA | |
| rs3406163990 | 1192 | Q>P | No | EVA | |
| rs3406063771 | 1193 | S>A | No | EVA | |
| rs3406089099 | 1196 | R>L | No | EVA | |
| rs3389352536 | 1223 | E>V | No | EVA | |
| rs219311587 | 1242 | G>D | No | EVA |
No associated diseases with G3UYX5
4 regional properties for G3UYX5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 394 - 556 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 150 - 226 | IPR011545-1 |
| domain | DEAD/DEAH box helicase domain | 298 - 367 | IPR011545-2 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 142 - 398 | IPR014001 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| fibrillar center | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. |
| male germ cell nucleus | The nucleus of a male germ cell, a reproductive cell in males. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| G-protein alpha-subunit binding | Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NE09 | RGS22 | Regulator of G-protein signaling 22 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPEKRLSAEP | PEVTEEEFEN | YLATDNFLVD | YFNEFLSLPT | FPEAIRFNVD | YGVFEVVNDA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PQLLEKQLKK | ILQNQQPRNP | IYDVVRKGKS | DSKSTQKSVP | CEDEAINVNY | SIMCLKREQG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| INWIKRERLP | AFLESDCYFE | YRLAKLISQA | TWSSTGMNFI | VGTNFTPWIL | RRPPAPPPPS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TDEDNYMIMK | KFYVSLGQAS | YTQTKDWFTL | AKESENTVTM | ASLPCCIPHH | QTASPVIATA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SEIFDDGVHP | RTIKSLSKSS | KAVSELDEEE | EGSISMKDSP | SQALLRVYLE | KKGGKERNLT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LHFSSVEEFL | DAYIIFILRE | AIQHITGQSL | SDTPEYINYY | KVSHVIFDKV | PPVPSNKAIV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPPVEMVEEI | SKDRLENVSL | SSESESIGPE | SRADWCISHR | TYDIGNRREF | ERFKKFLKGT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LGERYWWLWM | DIERLKVLKD | PERHQRHLEK | MKKCYLVSSG | ERYLSAEILS | KFKLLHGSRW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TADHLKNIQA | EVLKPLLLYW | APRFCVTHSA | SAKNASTELK | FWRLRQEKPR | KDVDPFPQMA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLLPLRPKSC | IPQTPEVQGE | EINLFQPSKF | KKLSKINAGT | QQLGRSEPLN | AVSSKDGGLE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KGSKRLPEST | TVVRLTSFTD | ISECLKPQLE | RKYTYTEEHN | VKTVSNVGAL | GGFDMENLLQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SLYVENRAGF | FFTKFCENSG | NKLWKHSVYF | WFDLQAYHQL | FYQETLQPFK | VCKQAQYLFA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TYIAPSASFD | IGLHQEGKKD | IYMKIQPPFE | DLFDTAEEFI | LLSLLEPWTQ | MVMSDKMAYK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KVELQEETRQ | LDSACFRKLH | ALHKETISKK | AEDTTGYAMA | KLSLSDVSKQ | TEYWLNVPEG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| YKHFTFTDLL | NNKLEFEHFR | QFLESHSSSL | DLMCWIDIEQ | FRRIIFKDQK | QREEKSIYIK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NKYLNKKYFF | GPRSPASLHQ | QNQIMLLSGG | WGRILHEQLD | ASVLVEIQKH | VLNRLENVWL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PLFLSSEQFA | SRQKIKTQMK | DIADELLLQR | HDRKIGVWKP | VESKWISSSC | EIIAFRKALL |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| NPVIARQFQR | FVALKGDLLE | NGVLFWQEVQ | KFKDLCHSHC | DESIIHKKIT | TIINCFINSY |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| IPPALQIDIP | VEQAQKILEH | RKELGPYVFR | EAQMTIFGVL | FKFWPQFCEF | RKNLTDEKIM |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| SVLERRQEHK | QKRKASDTEE | DKAGKSGVKQ | YASTTGSLTK | PVLGSESLLV | LQSYGRQPTW |
| 1210 | 1220 | 1230 | 1240 | 1250 | |
| CYSKYIEALE | QERILLKIQE | EVERKMFTGT | SSFTNLLKPS | TGSALSLKKN | VSLHSIQR |