G0SFH5

PR
Gene name
NUP188 (CTHT_0070850)
Protein name
Nucleoporin NUP188
Names
Nuclear pore protein NUP188
Species
Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) (Thermochaetoides thermophila)
KEGG Pathway
cthr:CTHT_0070850
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

406-478 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for G0SFH5

Entry ID Method Resolution Chain Position Source
5CWU X-ray 335 A A/B/C/D/E/F/G/H 1447-1858 PDB
7MVW X-ray 276 A A 1-1134 PDB
7MVX X-ray 435 A A 1-1858 PDB
7MVY EM 239 A A 1-1858 PDB
7MVZ EM 281 A A 1-1858 PDB
AF-G0SFH5-F1 Predicted AlphaFoldDB

No variants for G0SFH5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for G0SFH5

No associated diseases with G0SFH5

3 regional properties for G0SFH5

Type Name Position InterPro Accession
domain Nucleoporin Nup188, N-terminal 173 - 421 IPR018864-1
domain Nucleoporin Nup188, N-terminal 646 - 1147 IPR018864-2
domain Nuclear pore protein Nup188, C-terminal 1456 - 1849 IPR041634

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nuclear pore complex
  • Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side
  • Symmetric distribution
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.

1 GO annotations of molecular function

Name Definition
structural constituent of nuclear pore The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.

2 GO annotations of biological process

Name Definition
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATLTDRTYL PPLEDCLTGR TVILSWRLVA SALEDADLAR LTSPALSTFL RDGFVHELLK
70 80 90 100 110 120
HPARVFEPKD LKQEFETKTS SIQTVAPGVD TIKKDALWLA DAVAINQVAA LRIVLIEYQT
130 140 150 160 170 180
RAHSHLVLPL STQDVANIQE AAGVGDAHAS SILSLLNPAS AVDAETMWCD FETEARRRER
190 200 210 220 230 240
ILATYLSERR SFTAAVDALV TFLLHSAPGQ HKDLDSLRRA LLKDAFAFDE DLDVPDRSKL
250 260 270 280 290 300
LTMAPTYMNL VEDCIARAQA LPAKLGESFK TEAFELDWLR TAITEAVHSL SIAFQALDLD
310 320 330 340 350 360
TPYFAPHELL SEWFELMNSS LFLESILGFE VVADLAMPAR SLVSAICLKM LNIDRTIQFL
370 380 390 400 410 420
HDFDYPDGEE PYLLSSQTLN KIHTAVTNAV NSGVAASLPV AFAWSLIVHQ MHLGYQERAE
430 440 450 460 470 480
RRDLLVNQRA QAGFELEFQP SASTPNRRRR NSAGSIVSLE ASPYDDFLRE QRLDNDIAPV
490 500 510 520 530 540
EQIAMLATSR GQVYQVMSEM ALCLGTTHEA AFRPAVGARA RLVFQDLLKR SAYLIPYQDE
550 560 570 580 590 600
PVFSLLAILA TGRQYWDVTD ALSASSLNQV YTDMLDDETL FTQFTMQAIN RFPYEFNPFS
610 620 630 640 650 660
VLCRVLAAAL ITNKDKADVV TGWLWRTPTL TVDWNPAWDR SYELCFEDEN TNSFRLTRDV
670 680 690 700 710 720
DLFGSASPAR PRHLAAEERF IIPEGTLGRF VTDVGRTARL EFEHSALALL GKRLEVKAAE
730 740 750 760 770 780
EICDSGMAPL DVDEQAEAVA MLATVLRAES LKSTAKGGDP EAPLKFLKEA SRLLPHNKDI
790 800 810 820 830 840
LTVISDTIDG LVEKELLELD GPQIAVLASC LQFLHAALAV CPGRVWAYMS RCALIAGDAR
850 860 870 880 890 900
PGRLSRITGS LDMYAERFDL LSSAVKLFAA LIDSAACSAV QRRAGSTALV SVRSAVENPW
910 920 930 940 950 960
LGTSEKILSR VALAIAQAAL DVYESTTTWR FRSELDRSIL VRDVVGLMHK LVVHAHTLSS
970 980 990 1000 1010 1020
HLTSTLSPAA AHIISSFLTP PPSASSLRFQ PLLGTLLVAL ITPRATLYPG QSRILAERVT
1030 1040 1050 1060 1070 1080
SVLAFCTSLL RAADFLGQTH IPLQTHLFQS ACLLARLPAA NAVYRAPVLE LLRALVEVAG
1090 1100 1110 1120 1130 1140
RAANGSGEPP SLLGYLGSHA ARSFISLVEG IDKPFGRVEH AVVTWRFFAA VIRNRQQWMA
1150 1160 1170 1180 1190 1200
GCLLTGRTPR EALKGGGEQK IERKVGEGSV LAAAMERLRE VKSLDVQEAV AVMDFVVSAQ
1210 1220 1230 1240 1250 1260
NYWPWTIFAV RKEKEVVDAL RGYVRGLKAP GMVMKTDGAA AAAFQARIAA YVAETFAMQL
1270 1280 1290 1300 1310 1320
YHMRQMRQAE KFAGELVADL DYFLREGVMV WGYNASLHGN FARNFAKRFP GVEVDDFKRT
1330 1340 1350 1360 1370 1380
MWLPRELGKG YYYALEVAEQ MLGFDAGWGG VKQSGFRKEM ETANLNLSLV EAQVSLFHAW
1390 1400 1410 1420 1430 1440
EYLLLELTLS LLPKKENAAF ARQVLQVVEQ CLEANQRSQP PENIFVVLGH ARAGLALTLL
1450 1460 1470 1480 1490 1500
QRLADANQLP RDVTHLLALV SSAIHAVENP FGANDLPYFR TLLKILFVVL RAAKQGTAKP
1510 1520 1530 1540 1550 1560
GESNVAITQQ VLTILDRVVA RCFRALAALV HEQQQNATDG TTTAPEDLAL ITAILQACLS
1570 1580 1590 1600 1610 1620
VPGIEQCQVQ VLNIMAAHDV FQVAVALFSW ADRLLPANPS PASSSTSTSA TNPASGDPVY
1630 1640 1650 1660 1670 1680
GELALLFLLE LSALPALAEH LACDGLLGHL AAARLAGYMR RTNVGPFAEN AGAARCYAIW
1690 1700 1710 1720 1730 1740
AKCLLPLLLN ILAALGSTVA PEVAWVLNQF PNLLQSSVER IEPPGFSRPT LSLASTPPRQ
1750 1760 1770 1780 1790 1800
KFISLLEISE IHSLALLTRV LAACRAQNAR DVPEVTWDGA KVLECVEYWL RGRKVLRERL
1810 1820 1830 1840 1850
VPLGPREVEW RGMVATGGVV GVAGDGGEGC ENRLEEKAVG LLVGVREVLE GGLEGEGE