F7FIH8

PR
Gene name
NAXE
Protein name
NAD(P)H-hydrate epimerase
Names
Apolipoprotein A-I-binding protein, AI-BP, NAD(P)HX epimerase
Species
Monodelphis domestica (Gray short-tailed opossum)
KEGG Pathway
mdo:100018290
EC number
5.1.99.6: Acting on other compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-71 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F7FIH8

Entry ID Method Resolution Chain Position Source
AF-F7FIH8-F1 Predicted AlphaFoldDB

No variants for F7FIH8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for F7FIH8

No associated diseases with F7FIH8

1 regional properties for F7FIH8

Type Name Position InterPro Accession
domain YjeF N-terminal domain 56 - 271 IPR004443

Functions

Description
EC Number 5.1.99.6 Acting on other compounds
Subcellular Localization
  • Mitochondrion
  • Secreted
  • In sperm, secretion gradually increases during capacitation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cell body The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
metal ion binding Binding to a metal ion.
NADHX epimerase activity Catalysis of the reaction: (R)-NADHX = (S)-NADHX.
NADPHX epimerase activity Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

6 GO annotations of biological process

Name Definition
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
membrane raft distribution The process that establishes the spatial arrangement of membrane rafts within a cellular membrane.
negative regulation of angiogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
nicotinamide nucleotide metabolic process The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.
regulation of cholesterol efflux Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
sprouting angiogenesis The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGLRTLLGL GLLVSSSRFP RVVARGGPRC PGPAWWAARP MHLGDSTMAG GTVKYLSQEE
70 80 90 100 110 120
AQAVDEELFN EYKFSVDQLM ELAGLSCATA IAKAYPLSSF GSNPPAVLVI CGPGNNGGDG
130 140 150 160 170 180
LVCARHLKLF GYEPKIHYPK KPNKPLFDAL VTQCQKMDIP FLPEVPPEPM LIDELYELVV
190 200 210 220 230 240
DAIFGFSFKG AVREPFGTIL SIMNGLTVPI ASIDIPSGWD VEKGNPEGIR PDLLISLTAP
250 260 270 280
KKAATLFKGR HHYLGGRFVP SDLEKKYQLN LPPYPGTDCV LQLQ