F7CYY5

PR
Gene name
impdh2
Protein name
Inosine-5'-monophosphate dehydrogenase 2
Names
IMP dehydrogenase 2, IMPD 2, IMPDH 2
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
EC number
1.1.1.205: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

387-462 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F7CYY5

Entry ID Method Resolution Chain Position Source
AF-F7CYY5-F1 Predicted AlphaFoldDB

No variants for F7CYY5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for F7CYY5

No associated diseases with F7CYY5

4 regional properties for F7CYY5

Type Name Position InterPro Accession
domain CBS domain 114 - 173 IPR000644-1
domain CBS domain 176 - 238 IPR000644-2
domain IMP dehydrogenase/GMP reductase 29 - 505 IPR001093
conserved_site IMP dehydrogenase / GMP reductase, conserved site 322 - 334 IPR015875

Functions

Description
EC Number 1.1.1.205 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Cytoplasm, cytosol
  • Can form fiber-like subcellular structures termed 'cytoophidia' in response to intracellular guanine-nucleotide depletion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
IMP dehydrogenase activity Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
metal ion binding Binding to a metal ion.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

2 GO annotations of biological process

Name Definition
GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate.
GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P12268 IMPDH2 Inosine-5'-monophosphate dehydrogenase 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MADYLISGGT SYVPDDGLTA QQLFGAGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT
70 80 90 100 110 120
LKTPMVSSPM DTVTEASMAI AMALTGGIGI MHHNCTPEFQ ANEVRKVKKY EQGFITDPVV
130 140 150 160 170 180
LSPKHRVRDV FEAKARHGFC GIPITENGKM GSKLAGIISS RDIDFLKSEE HDLALSEIMT
190 200 210 220 230 240
RREDLVVAPA GVTLKEANEI LQRSKKGKLL PIVNGNDELV AIIARTDLKK NRDYPLASKD
250 260 270 280 290 300
AKKQLLCGAA IGTHEDDKYR LDLLVQAGVD AVVLDSSQGN SIFQINMIKF IKEKYQDLQV
310 320 330 340 350 360
IAGNVVTAAQ AKNLIDAGAD ALRVGMGSGS ICITQEVLAC GRPQATAVYK VSEYARRFGV
370 380 390 400 410 420
PVIADGGIQT VGHIAKALAL GASTVMMGSL LAATTEAPGE YFFSDGIRLK KYRGMGSLDA
430 440 450 460 470 480
MDKNVSSQKR YFSEADKIKV AQGVSGAVQD KGSIHKFIPY LIAGIQHSCQ DIGAKSLTQV
490 500 510
RAMMYSGELK FEKRTMSAQV EGGVHGLHSY EKRLF