F5HF68
Gene name |
vIRF-1 |
Protein name |
VIRF-1 |
Names |
|
Species |
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) |
KEGG Pathway |
vg:4961464 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
No variants for F5HF68
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for F5HF68 | |||||
No associated diseases with F5HF68
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| host cell cytoplasm | The cytoplasm of a host cell. |
| host cell nucleus | A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| transcription cis-regulatory region binding | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process. |
| suppression by virus of host protein-protein interaction | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins. |
| suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity | Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPGQRPNPF | GAPGAIPKKP | CLSQGSPGTS | GSGAPCDEPS | RSESPGEGPS | GTGGSAAAGD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ITRQAVVAAI | TEWSRTRQLR | ISTGASEGKA | SIKDWIVCQV | NSGKFPGVEW | EDEERTRFRI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVTPLADPCF | EWRRDGELGV | VYIRERGNMP | VDASFKGTRG | RRRMLAALRR | TRGLQEIGKG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ISQDGHHFLV | FRVRKPEEEQ | CVECGVVAGA | VHDFNNMARL | LQEGFFSPGQ | CLPGEIVTPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSCTTAEGQE | AVIDWGRLFI | RMYYNGEQVH | ELLTTSQSGC | RISSALRRDP | AVHYCAVGSP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GQVWLPNVPN | LACEIAKREL | CDTLDACAKG | ILLTSSCNGI | FCVCYHNGPV | HFIGNTVPPD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SGPLLLPQGK | PTRIFNPNTF | LVGLANSPLP | APSHVTCPLV | KLWLGKPVAV | GKLEPHAPSP |
| 430 | 440 | ||||
| RDFAARCSNF | SDACVVLEIM | PKPLWDAMQ |