F5HF62
Gene name |
US28 |
Protein name |
Envelope protein US28 |
Names |
|
Species |
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) |
KEGG Pathway |
vg:3077536 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for F5HF62
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for F5HF62
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for F5HF62 | |||||
No associated diseases with F5HF62
1 regional properties for F5HF62
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 50 - 291 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| host cell plasma membrane | The plasma membrane surrounding a host cell. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chemokine receptor activity | Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| mitigation of host antiviral defense response | A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| suppression by virus of host chemokine activity | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTPTTTTAEL | TTEFDYDEDA | TPCVFTDVLN | QSKPVTLFLY | GVVFLFGSIG | NFLVIFTITW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRRIQCSGDV | YFINLAAADL | LFVCTLPLWM | QYLLDHNSLA | SVPCTLLTAC | FYVAMFASLC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FITEIALDRY | YAIVYMRYRP | VKQACLFSIF | WWIFAVIIAI | PHFMVVTKKD | NQCMTDYDYL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVSYPIILNV | ELMLGAFVIP | LSVISYCYYR | ISRIVAVSQS | RHKGRIVRVL | IAVVLVFIIF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WLPYHLTLFV | DTLKLLKWIS | SSCEFERSLK | RALILTESLA | FCHCCLNPLL | YVFVGTKFRQ |
| 310 | 320 | 330 | 340 | 350 | |
| ELHCLLAEFR | QRLFSRDVSW | YHSMSFSRRG | SPSRRETSSD | TLSDEVCRVS | QIIP |